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Cellosaurus Evsa-T GDC-0941-resistant clone 1 (CVCL_A1FL)

[Text version]
Cell line name Evsa-T GDC-0941-resistant clone 1
Accession CVCL_A1FL
Resource Identification Initiative To cite this cell line use: Evsa-T GDC-0941-resistant clone 1 (RRID:CVCL_A1FL)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:65326; Pictrelisib (Pictilisib; GDC-0941).
Omics: Deep exome analysis.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 8976; PIK3CB; Simple; p.Asp1067Tyr (c.3199G>T); Zygosity=Heterozygous; Note=Responsible for pictrelisib resistance (PubMed=26759240).
  • Mutation; HGNC; 1748; CDH1; Simple; c.687+1_687+2delGT; ClinVar=VCV000483268; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.951_954delACTT) (p.VL317fs) (V317fs*3); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser241Cys (c.722C>G); ClinVar=VCV000177791; Zygosity=Homozygous (from parent cell line).
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1207 (Evsa-T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line

PubMed=26759240; DOI=10.1158/0008-5472.CAN-15-2201
Nakanishi Y., Walter K., Spoerke J.M., O'Brien C., Huw L.Y., Hampton G.M., Lackner M.R.
Activating mutations in PIK3CB confer resistance to PI3K inhibition and define a novel oncogenic role for p110beta.
Cancer Res. 76:1193-1203(2016)

Cell line databases/resources cancercelllines; CVCL_A1FL
Encyclopedic resources Wikidata; Q102113801
Polymorphism and mutation databases Cosmic; 2787555
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number7