Cellosaurus cell line M21R (CVCL

Cross-references
Cell line name	M21R
Synonyms	M21-R
Accession	CVCL_A1FB
Resource Identification Initiative	To cite this cell line use: M21R (RRID:CVCL_A1FB)
Comments	Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032). Derived from site: Metastatic; Not specified.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=24732172).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_D031 (M21)
Sex of cell	Female
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=24732172; DOI=10.18632/oncotarget.1878; PMCID=PMC4039118 Sabbatino F., Wang Y.-Y., Wang X.-H., Flaherty K.T., Yu L., Pepin D., Scognamiglio G., Pepe S., Kirkwood J.M., Cooper Z.A., Frederick D.T., Wargo J.A., Ferrone S., Ferrone C.R. PDGFRalpha up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation. Oncotarget 5:1926-1941(2014)
Cell line databases/resources	cancercelllines; CVCL_A1FB
Encyclopedic resources	Wikidata; Q102114490
Polymorphism and mutation databases	Cosmic; 2757121
Entry history
Entry creation	29-Oct-2020
Last entry update	19-Dec-2024
Version number	7