Cellosaurus cell line ABC-17 (CVCL

Cellosaurus ABC-17 (CVCL_A1EG)

Cross-references
Cell line name	ABC-17
Accession	CVCL_A1EG
Resource Identification Initiative	To cite this cell line use: ABC-17 (RRID:CVCL_A1EG)
Comments	Population: Japanese. Characteristics: Established from a xenograft produced by subcutaneous injection of tumor cells into NOG (NOD/Shi-scid, IL-2RgammaKO Jic) mice. Characteristics: Resistant to alectinib and crizotinib. Omics: Transcriptome analysis by RNAseq. Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations	Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK (PubMed=31374369). Mutation; HGNC; HGNC:427; ALK; Simple; p.Gly1202Arg (c.3604G>A); ClinVar=VCV000376134; Zygosity=Unspecified (PubMed=31374369).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_A1EF ! ABC-14
Sex of cell	Male
Age at sampling	51Y
Category	Cancer cell line
Publications	PubMed=31374369; DOI=10.1016/j.jtho.2019.07.017 Makimoto G., Ohashi K., Tomida S., Nishii K., Matsubara T., Kayatani H., Higo H., Ninomiya K., Sato A., Watanabe H., Kano H., Ninomiya T., Kubo T., Rai K., Ichihara E., Hotta K., Tabata M., Toyooka S., Takata M., Maeda Y., Kiura K. Rapid acquisition of alectinib resistance in ALK-positive lung cancer with high tumor mutation burden. J. Thorac. Oncol. 14:2009-2018(2019)
Cell line databases/resources	cancercelllines; CVCL_A1EG
Encyclopedic resources	Wikidata; Q102113499
Polymorphism and mutation databases	Cosmic; 2843084
Entry history
Entry creation	29-Oct-2020
Last entry update	19-Dec-2024
Version number	7