ID   MDA-T248
AC   CVCL_A1CT
DR   cancercelllines; CVCL_A1CT
DR   Wikidata; Q102114524
RX   PubMed=34147031;
CC   Doubling time: 25.6 hours (PubMed=34147031).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=34147031).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp74Asn (c.220G>A); ClinVar=VCV000483340; Zygosity=Homozygous (PubMed=34147031).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.994-1G>C; ClinVar=VCV000232659; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=34147031).
CC   Miscellaneous: Age of donor from personal communication of Henderson, Ying C.
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
ST   Source(s): PubMed=34147031
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11
ST   D16S539: 11,13
ST   D5S818: 9,11
ST   D7S820: 11
ST   TH01: 6,8
ST   TPOX: 9,10
ST   vWA: 14,18
DI   NCIt; C3878; Thyroid gland anaplastic carcinoma
DI   ORDO; Orphanet_142; Anaplastic thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   70Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 19-12-24; Version: 9
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RX   PubMed=34147031; DOI=10.1210/clinem/dgab453; PMCID=PMC8530744;
RA   Maniakas A., Henderson Y.C., Hei H., Peng S.-H., Chen Y.-Y.,
RA   Jiang Y.-J., Ji S.-X., Cardenas M., Chiu Y.-L., Bell D., Williams M.D.,
RA   Hofmann M.-C., Scherer S.E., Wheeler D.A., Busaidy N.L., Dadu R.,
RA   Wang J.R., Cabanillas M.E., Zafereo M., Johnson F.M., Lai S.Y.;
RT   "Novel anaplastic thyroid cancer PDXs and cell lines: expanding
RT   preclinical models of genetic diversity.";
RL   J. Clin. Endocrinol. Metab. 106:e4652-e4665(2021).
//