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Cellosaurus LNCaP AR-V7/pLenti (CVCL_A1BL)

[Text version]
Cell line name LNCaP AR-V7/pLenti
Synonyms LNCaPAR-V7/pLenti
Accession CVCL_A1BL
Resource Identification Initiative To cite this cell line use: LNCaP AR-V7/pLenti (RRID:CVCL_A1BL)
Comments Population: Caucasian.
Characteristics: Inducibly expresses AR variant 7 (ARv7). Developed with the T-REx lentiviral Gateway expression system. Addition of doxycycline (Dox) relieves repression by tetR thus permitting ARv7 induction.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 644; AR (Note=Isoform ARv7).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1379 (LNCaP clone FGC)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=25008967; DOI=10.1016/j.biocel.2014.06.013; PMCID=PMC4160387
Krause W.C., Shafi A.A., Nakka M., Weigel N.L.
Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells.
Int. J. Biochem. Cell Biol. 54:49-59(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1BL
Encyclopedic resources Wikidata; Q102114472
Entry history
Entry creation29-Oct-2020
Last entry update10-Sep-2024
Version number8