| Cell line name |
MOLT4/P |
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| Accession |
CVCL_A1BB |
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| Resource Identification Initiative |
To cite this cell line use: MOLT4/P (RRID:CVCL_A1BB) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_71223; Pralatrexate (Folotyn).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0013 (MOLT-4) |
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| Sex of cell |
Male |
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| Age at sampling |
19Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=34332580; DOI=10.1186/s12885-021-08607-9; PMCID=PMC8325835
Oiwa K., Hosono N., Nishi R., Scotto L., O'Connor O.A., Yamauchi T.
Characterization of newly established pralatrexate-resistant cell lines and the mechanisms of resistance.
BMC Cancer 21:879.1-879.12(2021) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_A1BB
|
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| Encyclopedic resources |
Wikidata; Q102114554
|
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| Entry history |
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| Entry creation | 29-Oct-2020 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 8 |
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