ID   BON1-MEN1-KO
AC   CVCL_A1AU
SY   MEN1-KO-BON1
DR   cancercelllines; CVCL_A1AU
DR   Wikidata; Q102113642
RX   PubMed=32884006;
CC   Doubling time: 36 +- 0.48 hours (PubMed=32884006).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 7010; MEN1.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu1317Gln (c.3949G>C); ClinVar=VCV000000829; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Cys1960Tyr (c.5879G>A); ClinVar=VCV000038003; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg342Ter (c.1024C>T); ClinVar=VCV000182970; Zygosity=Homozygous (from parent cell line).
CC   Omics: Deep quantitative proteome analysis.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C4446; Pancreatic serotonin-producing neuroendocrine tumor
DI   ORDO; Orphanet_506090; Serotonin-producing neuroendocrine tumor of pancreas
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3985 ! BON-1
SX   Male
AG   28Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 10-09-24; Version: 7
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RX   PubMed=32884006; DOI=10.1038/s41598-020-71516-7; PMCID=PMC7471701;
RA   Monazzam A., Li S.-C., Wargelius H., Razmara M., Bajic D., Mi J.,
RA   Bergquist J., Crona J., Skogseid B.;
RT   "Generation and characterization of CRISPR/Cas9-mediated MEN1 knockout
RT   BON1 cells: a human pancreatic neuroendocrine cell line.";
RL   Sci. Rep. 10:14572-14572(2020).
//