Cellosaurus HeLa-SHMT2-shSHMT2 (CVCL_A1AR)
| Cell line name | HeLa-SHMT2-shSHMT2 |
|---|---|
| Synonyms | HeLa-Ss |
| Accession | CVCL_A1AR |
| Resource Identification Initiative | To cite this cell line use: HeLa-SHMT2-shSHMT2 (RRID:CVCL_A1AR) |
| Comments | Population: African American. Characteristics: Allows both a Tet-inducible over-expression of mouse Shmt2 and isopropyl beta-D-1-thiogalactopyranoside (IPTG)-inducible shRNA against SHMT2. Knockout cell: Method=shRNA knockdown; HGNC; 10852; SHMT2. Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:1277989; Shmt2. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR. Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002. |
| Disease | Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_D587 (T-REx-HeLa) |
| Sex of cell | Female |
| Age at sampling | 30Y6M |
| Category | Cancer cell line |
| Publications | PubMed=32903271; DOI=10.1371/journal.pone.0237981; PMCID=PMC7480864 |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q102114111 |
| Metabolomic databases | MetaboLights; MTBLS405 |
| Proteomic databases | PRIDE; PXD004629
PRIDE; PXD004954 |
| Entry history | |
| Entry creation | 29-Oct-2020 |
| Last entry update | 10-Sep-2024 |
| Version number | 8 |