Cellosaurus logo
expasy logo

Cellosaurus Ma-Mel-40 (CVCL_A176)

[Text version]
Cell line name Ma-Mel-40
Synonyms Ma-Mel_40; Ma-Mel 40; MaMel40
Accession CVCL_A176
Resource Identification Initiative To cite this cell line use: Ma-Mel-40 (RRID:CVCL_A176)
Comments Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=20544847).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): ESTDAB=ESTDAB-212

Markers:
AmelogeninX,Y
CSF1PO10,11
D3S135816,17
D5S81810,13
D7S8208,10
D13S31711
FGA24
TH019,9.3
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R., Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D., Dummer R.
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595
Ugurel S., Thirumaran R.K., Bloethner S., Gast A., Sucker A., Mueller-Berghaus J., Rittgen W., Hemminki K., Becker J.C., Kumar R., Schadendorf D.
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
PLoS ONE 2:E236-E236(2007)

PubMed=20544847; DOI=10.1002/gcc.20785
Gast A., Scherer D., Chen B.-W., Bloethner S., Melchert S., Sucker A., Hemminki K., Schadendorf D., Kumar R.
Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study.
Genes Chromosomes Cancer 49:733-745(2010)

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A176
ESTDAB; ESTDAB-212
IGRhCellID; MaMel40
Encyclopedic resources Wikidata; Q54903794
Gene expression databases GEO; GSM109064
GEO; GSM437007
Polymorphism and mutation databases Cosmic; 1467756
Cosmic; 1846621
Cosmic; 2686405
Progenetix; CVCL_A176
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number19