ID   Ma-Mel-114
AC   CVCL_A137
SY   MaMel114
DR   cancercelllines; CVCL_A137
DR   Cosmic; 1467787
DR   Cosmic; 1846582
DR   Cosmic; 2686354
DR   GEO; GSM437037
DR   IGRhCellID; MaMel114new
DR   Progenetix; CVCL_A137
DR   Wikidata; Q54903748
RX   PubMed=17311103;
RX   PubMed=20544847;
RX   PubMed=23348503;
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Leu130Arg (c.389T>G); Zygosity=Unspecified (PubMed=20544847).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-101C>T (c.205C>T) (C101T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser127Phe (c.380C>T); ClinVar=VCV000182928; Zygosity=Unspecified (PubMed=20544847).
CC   Omics: SNP array analysis.
CC   Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 18
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RX   PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595;
RA   Ugurel S., Thirumaran R.K., Bloethner S., Gast A., Sucker A.,
RA   Mueller-Berghaus J., Rittgen W., Hemminki K., Becker J.C., Kumar R.,
RA   Schadendorf D.;
RT   "B-RAF and N-RAS mutations are preserved during short time in vitro
RT   propagation and differentially impact prognosis.";
RL   PLoS ONE 2:E236-E236(2007).
//
RX   PubMed=20544847; DOI=10.1002/gcc.20785;
RA   Gast A., Scherer D., Chen B.-W., Bloethner S., Melchert S., Sucker A.,
RA   Hemminki K., Schadendorf D., Kumar R.;
RT   "Somatic alterations in the melanoma genome: a high-resolution
RT   array-based comparative genomic hybridization study.";
RL   Genes Chromosomes Cancer 49:733-745(2010).
//
RX   PubMed=23348503; DOI=10.1126/science.1230062;
RA   Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A.,
RA   Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.;
RT   "TERT promoter mutations in familial and sporadic melanoma.";
RL   Science 339:959-961(2013).
//