Cellosaurus cell line ZMAC-4 (CVCL

Cellosaurus ZMAC-4 (CVCL_A0XV)

Cross-references
Cell line name	ZMAC-4
Synonyms	ZMAC1107-4; Zuckermann MACrophage-4
Accession	CVCL_A0XV
Resource Identification Initiative	To cite this cell line use: ZMAC-4 (RRID:CVCL_A0XV)
Comments	Characteristics: CSF1 dependent. Virology: Susceptible to infection by porcine reproductive and respiratory syndrome virus (PRRSV) (PubMed=21191013). Virology: Supports high level of replication of African swine fever virus attenuated strain OURT88/3 (PubMed=32515659). Doubling time: 3.9 +- 0.3 days (PubMed=32515659). Derived from site: In situ; Fetal lung, alveolus; UBERON=UBERON_0005597+UBERON_0002299. Cell type: Alveolar macrophage; CL=CL_0000583.
Species of origin	Sus scrofa (Pig) (NCBI Taxonomy: 9823) Breed/subspecies: Landrace x Yorkshire x Duroc; VBO=VBO_0001161+VBO_0001212+VBO_0001127.
Sex of cell	Sex unspecified
Age at sampling	60FD
Category	Factor-dependent cell line
Publications	PubMed=21191013; DOI=10.1128/JVI.01616-10; PMCID=PMC3067927 Calzada-Nova G., Schnitzlein W.M., Husmann R.J., Zuckermann F.A. North American porcine reproductive and respiratory syndrome viruses inhibit type I interferon production by plasmacytoid dendritic cells. J. Virol. 85:2703-2713(2011) Patent=US9169465 Zuckermann F.A. Non-simian cells for growth of porcine reproductive and respiratory syndrome (PRRS) virus. Patent number US9169465, 27-Oct-2015 PubMed=32515659; DOI=10.1080/22221751.2020.1772675; PMCID=PMC7448849 Portugal R., Goatley L.C., Husmann R.J., Zuckermann F.A., Dixon L.K. A porcine macrophage cell line that supports high levels of replication of OURT88/3, an attenuated strain of African swine fever virus. Emerg. Microbes Infect. 9:1245-1253(2020)
Encyclopedic resources	Wikidata; Q108821563
Entry history
Entry creation	23-Sep-2021
Last entry update	10-Sep-2024
Version number	7