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Cellosaurus MS-EwS-6 (CVCL_A0VN)

[Text version]
Cell line name MS-EwS-6
Synonyms MS-PES-6
Accession CVCL_A0VN
Resource Identification Initiative To cite this cell line use: MS-EwS-6 (RRID:CVCL_A0VN)
Comments Miscellaneous: Gene fusion, site of sampling and age of donor from personal communication of Rossig, Claudia.
Derived from site: Metastatic; Thoracic cavity; UBERON=UBERON_0002224.
Sequence variations
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1 (Direct_author_submission).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): PubMed=30879952

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135814
D5S81813
D7S82012,13
D13S3178,13
D16S5398,11
FGA20,24
TH016
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=29464090; DOI=10.18632/oncotarget.23815; PMCID=PMC5814230
Spurny C., Kailayangiri S., Altvater B., Jamitzky S., Hartmann W., Wardelmann E., Ranft A., Dirksen U., Amler S., Hardes J., Fluegge M., Meltzer J., Farwick N., Greune L., Rossig C.
T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G.
Oncotarget 9:6536-6549(2018)

PubMed=30879952; DOI=10.1016/j.ymthe.2019.02.014; PMCID=PMC6520468
Kailayangiri S., Altvater B., Lesch S., Balbach S.T., Gottlich C., Kuhnemundt J., Mikesch J.-H., Schelhaas S., Jamitzky S., Meltzer J., Farwick N., Greune L., Fluegge M., Kerl K., Lode H.N., Siebert N., Muller I., Walles H., Hartmann W., Rossig C.
EZH2 inhibition in Ewing sarcoma upregulates GD2 expression for targeting with gene-modified T cells.
Mol. Ther. 27:933-946(2019)

Cross-references
Encyclopedic resources Wikidata; Q108820994
Entry history
Entry creation23-Sep-2021
Last entry update19-Dec-2024
Version number6