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Cellosaurus THP18-deltaA3A/B (CVCL_A0HC)

[Text version]
Cell line name THP18-deltaA3A/B
Accession CVCL_A0HC
Resource Identification Initiative To cite this cell line use: THP18-deltaA3A/B (RRID:CVCL_A0HC)
Comments Population: Japanese.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17343; APOBEC3A.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17352; APOBEC3B.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A0HA (THP18)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Publications

PubMed=31544853; DOI=10.3390/antib8030047; PMCID=PMC6783943
Brown W.L., Law E.K., Argyris P.P., Carpenter M.A., Levin-Klein R., Ranum A.N., Molan A.M., Forster C.L., Anderson B.D., Lackey L., Harris R.S.
A rabbit monoclonal antibody against the antiviral and cancer genomic DNA mutating enzyme APOBEC3B.
Antibodies (Basel) 8:47.1-47.17(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A0HC
Encyclopedic resources Wikidata; Q108821371
Entry history
Entry creation23-Sep-2021
Last entry update19-Dec-2024
Version number6