ID   LAP-35
AC   CVCL_A096
SY   LAP35; IOR/LAP-35; IOR-LAP-35
DR   Cosmic; 1078388
DR   Cosmic; 1082509
DR   Wikidata; Q54901922
RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RX   DOI=10.5282/edoc.27750;
RX   PubMed=2177080;
RX   PubMed=8040301;
RX   PubMed=8617485;
RX   PubMed=11423975;
RX   PubMed=11891184;
RX   PubMed=18160777;
CC   From: Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli; Bologna; Italy.
CC   Doubling time: 49 hours (PubMed=2177080).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=18160777).
CC   Sequence variation: Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 2 fusion (Ex7/Ex5) (PubMed=8040301; PubMed=11423975; PubMed=11891184).
CC   Omics: Array-based CGH.
DI   NCIt; C8776; Peripheral primitive neuroectodermal tumor of bone
DI   ORDO; Orphanet_370348; Peripheral primitive neuroectodermal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   12Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 21-03-23; Version: 22
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RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RA   Israel M.A., Thiele C.J.;
RT   "Tumor cell lines of the peripheral nervous system.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).
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RX   DOI=10.5282/edoc.27750;
RA   Orth M.F.;
RT   "Systematic multi-omics profiling of Ewing sarcoma cell lines.";
RL   Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany.
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RX   PubMed=2177080; DOI=10.1002/stem.5530080644;
RA   Bagnara G.P., Serra M., Giovannini M., Badiali M., Stella M.,
RA   Montaldi A., Granchi D., Paolucci P., Rocchi P., Pession A., Picci P.,
RA   Paolucci G., Campanacci M., Tessarollo L., Cavazzana A.O.;
RT   "Establishment and characterization of a primitive neuroectodermal
RT   tumor of bone continuous cell line (LAP-35).";
RL   Int. J. Cell Cloning 8:409-424(1990).
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RX   PubMed=8040301; DOI=10.1172/JCI117360; PMCID=PMC295111;
RA   Giovannini M., Biegel J.A., Serra M., Wang J.-Y., Wei Y.-L.H.,
RA   Nycum L.M., Emanuel B.S., Evans G.A.;
RT   "EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and
RT   primitive neuroectodermal tumors with variant translocations.";
RL   J. Clin. Invest. 94:489-496(1994).
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RX   PubMed=8617485; DOI=10.1016/S0046-8177(96)90115-X;
RA   Scotlandi K., Serra M., Manara M.C., Benini S., Sarti M., Maurici D.,
RA   Lollini P.-L., Picci P., Bertoni F., Baldini N.;
RT   "Immunostaining of the p30/32MIC2 antigen and molecular detection of
RT   EWS rearrangements for the diagnosis of Ewing's sarcoma and peripheral
RT   neuroectodermal tumor.";
RL   Hum. Pathol. 27:408-416(1996).
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RX   PubMed=11423975; DOI=10.1038/sj.onc.1204437;
RA   Dauphinot L., De Oliveira C., Melot T., Sevenet N., Thomas V.,
RA   Weissman B.E., Delattre O.;
RT   "Analysis of the expression of cell cycle regulators in Ewing cell
RT   lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression.";
RL   Oncogene 20:3258-3265(2001).
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RX   PubMed=11891184; DOI=10.1016/S0002-9440(10)64908-5; PMCID=PMC1867180;
RA   Manara M.C., Perbal B., Benini S., Strammiello R., Cerisano V.,
RA   Perdichizzi S., Serra M., Astolfi A., Bertoni F., Alami J., Yeger H.,
RA   Picci P., Scotlandi K.;
RT   "The expression of ccn3(nov) gene in musculoskeletal tumors.";
RL   Am. J. Pathol. 160:849-859(2002).
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RX   PubMed=18160777; DOI=10.1159/000109614;
RA   Savola S., Nardi F., Scotlandi K., Picci P., Knuutila S.;
RT   "Microdeletions in 9p21.3 induce false negative results in CDKN2A FISH
RT   analysis of Ewing sarcoma.";
RL   Cytogenet. Genome Res. 119:21-26(2007).
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