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Cellosaurus YCUB-2 (CVCL_A082)

[Text version]
Cell line name YCUB-2
Synonyms YCUB2; YcuB2; Yokohama City University BCP-ALL-2
Accession CVCL_A082
Resource Identification Initiative To cite this cell line use: YCUB-2 (RRID:CVCL_A082)
Comments Population: Japanese.
Doubling time: ~24 hours (DSMZ=ACC-961).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Disease B acute lymphoblastic leukemia with TCF3-HLF rearrangement (NCIt: C199241)
B-lymphoblastic leukemia/lymphoma with t(17;19) (ORDO: Orphanet_641375)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-961

Markers:
AmelogeninX,Y
CSF1PO12
D2S133820,23
D3S135817,18
D5S81811,12
D7S82010,11
D8S117914,15
D13S3178,11
D16S5399
D18S5113
D19S43313
D21S1129,33.2
FGA21,22
Penta D11
Penta E11,16
TH017,8
TPOX8,9
vWA18

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Publications

PubMed=11417493; DOI=10.1038/sj.leu.2402120
Takahashi H., Goto H., Funabiki T., Fujii H., Yamazaki S., Fujioka K., Ikuta K., Kai S.
Expression of two types of E2A-HLF fusion proteins in YCUB-2, a novel cell line established from B-lineage leukemia with t(17;19).
Leukemia 15:995-997(2001)

PubMed=19157546; DOI=10.1016/j.leukres.2008.12.003
Goto H., Naruto T., Tanoshima R., Kato H., Yokosuka T., Yanagimachi M., Fujii H., Yokota S., Komine H.
Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children.
Leuk. Res. 33:1386-1391(2009)

PubMed=20147975; DOI=10.1038/leu.2010.8
Akahane K., Inukai T., Inaba T., Kurosawa H., Look A.T., Kiyokawa N., Fujimoto J., Goto H., Endo M., Zhang X., Hirose K., Kuroda I., Honna H., Kagami K., Goi K., Nakazawa S., Sugita K.
Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor.
Leukemia 24:865-869(2010)

PubMed=20519628; DOI=10.1182/blood-2009-09-244673
Hirose K., Inukai T., Kikuchi J., Furukawa Y., Ikawa T., Kawamoto H., Oram S.H., Gottgens B., Kiyokawa N., Miyagawa Y., Okita H., Akahane K., Zhang X.-C., Kuroda I., Honna H., Kagami K., Goi K., Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Blood 116:962-970(2010)

PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455
Inukai T., Zhang X.-R., Kameyama T., Suzuki Y., Yoshikawa K., Kuroda I., Nemoto A., Akahane K., Sato H., Goi K., Nakamoto K., Hamada J.-i., Tada M., Moriuchi T., Sugita K.
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
Am. J. Hematol. 85:535-537(2010)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H., Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T., Sugita K., Hosoi H.
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=32144432; DOI=10.1007/s00280-020-04045-9
Goto H., Yoshino Y., Ito M., Nagai J.-i., Kumamoto T., Inukai T., Sakurai Y., Miyagawa N., Keino D., Yokosuka T., Iwasaki F., Hamanoue S., Shiomi M., Goto S.
Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia.
Cancer Chemother. Pharmacol. 85:773-783(2020)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C., Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H., Minegishi M., Iwamoto S., Sugita K., Inukai T.
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-961
Encyclopedic resources Wikidata; Q54995372
Polymorphism and mutation databases IARC_TP53; 28430
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number14