Cellosaurus logo
expasy logo

Cellosaurus WSU-CLL (CVCL_A049)

[Text version]
Cell line name WSU-CLL
Accession CVCL_A049
Resource Identification Initiative To cite this cell line use: WSU-CLL (RRID:CVCL_A049)
Comments Problematic cell line: Contaminated. Shown to be a Reh derivative (PubMed=12200708; PubMed=12592342; PubMed=20143388; PubMed=24923861). Originally thought to originate from a 68 year old male patient with chronic lymphocytic leukemia.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00285.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 3495; ETV6 + HGNC; 10471; RUNX1; Name(s)=ETV6-RUNX1; TEL-AML1 (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Arg173Cys (c.517C>T); ClinVar=VCV000189500; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg181Cys (c.541C>T); ClinVar=VCV000142624; Zygosity=Heterozygous (from parent cell line).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) ETV6-RUNX1 (NCIt: C80334)
B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) (ORDO: Orphanet_585929)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1650 (Reh)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Web pages https://iclac.org/education/wsu-cll/

Mohammad R.M., Mohamed A.N., Hamdan M.Y., Vo T., Chen B., Katato K., Abubakr Y.A., Dugan M.C., Al-Katib A.
Establishment of a human B-CLL xenograft model: utility as a preclinical therapeutic model.
Leukemia 10:130-137(1996)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12200708; DOI=10.1038/sj.leu.2402610
Drexler H.G., Quentmeier H., Dirks W.G., Uphoff C.C., MacLeod R.A.F.
DNA profiling and cytogenetic analysis of cell line WSU-CLL reveal cross-contamination with cell line REH (pre B-ALL).
Leukemia 16:1868-1870(2002)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=24923861; DOI=10.1016/j.leukres.2014.05.003
International Cell Line Authentication Committee (ICLAC)
Cell line cross-contamination: WSU-CLL is a known derivative of REH and is unsuitable as a model for chronic lymphocytic leukaemia.
Leuk. Res. 38:999-1001(2014)

Cell line databases/resources cancercelllines; CVCL_A049
Biological sample resources BioSample; SAMN03151907
Encyclopedic resources Wikidata; Q29958010
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number28