ID   PC14PE6
AC   CVCL_9W70
SY   PC14-PE6; PC14/PE6
DR   cancercelllines; CVCL_9W70
DR   Wikidata; Q54938560
RX   PubMed=10741721;
RX   PubMed=10987313;
RX   PubMed=19771249;
CC   Problematic cell line: Contaminated. Parent cell line (PC-14) has been shown to be a PC-9 derivative.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Caution: PC-14-PM4 (Cellosaurus=CVCL_9W69) and PC14PE6 could be identical.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1640 ! PC-14
SX   Male
AG   45Y
CA   Cancer cell line
DT   Created: 23-02-16; Last updated: 05-10-23; Version: 14
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RX   PubMed=10741721;
RA   Yano S., Herbst R.S., Shinohara H., Knighton B., Bucana C.D.,
RA   Killion J.J., Wood J., Fidler I.J.;
RT   "Treatment for malignant pleural effusion of human lung adenocarcinoma
RT   by inhibition of vascular endothelial growth factor receptor tyrosine
RT   kinase phosphorylation.";
RL   Clin. Cancer Res. 6:957-965(2000).
//
RX   PubMed=10987313;
RA   Yano S., Shinohara H., Herbst R.S., Kuniyasu H., Bucana C.D.,
RA   Ellis L.M., Davis D.W., McConkey D.J., Fidler I.J.;
RT   "Expression of vascular endothelial growth factor is necessary but not
RT   sufficient for production and growth of brain metastasis.";
RL   Cancer Res. 60:4959-4967(2000).
//
RX   PubMed=19771249; DOI=10.4143/crt.2006.38.4.234;
RA   Cui Z.-Y., Ahn J.-S., Lee J.-Y., Kim W.-S., Lim H.-Y., Jeon H.-J.,
RA   Suh S.-W., Kim J.-H., Kong W.-H., Kang J.-M., Nam D.-H., Park K.;
RT   "Mouse orthotopic lung cancer model induced by PC14PE6.";
RL   Cancer Res. Treat. 38:234-239(2006).
//