Cell line name |
MDA-MB-231-5a-D |
Synonyms |
MDA-231-D |
Accession |
CVCL_9U31 |
Resource Identification Initiative |
To cite this cell line use: MDA-MB-231-5a-D (RRID:CVCL_9U31) |
Comments |
Group: Triple negative breast cancer (TNBC) cell line. Population: Caucasian. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
|
Disease |
Breast adenocarcinoma (NCIt: C5214) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_9U30 (MDA-MB-231-5a) Children:
|
Sex of cell |
Female |
Age at sampling |
51Y |
Category |
Cancer cell line |
Publications | PubMed=17129361; DOI=10.1111/j.1349-7006.2006.00357.x; PMCID=PMC11159712 Ehata S., Hanyu A., Fujime M., Katsuno Y., Fukunaga E., Goto K., Ishikawa Y., Nomura K., Yokoo H., Shimizu T., Ogata E., Miyazono K., Shimizu K., Imamura T. Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line. Cancer Sci. 98:127-133(2007) PubMed=18663362; DOI=10.1038/onc.2008.232 Katsuno Y., Hanyu A., Kanda H., Ishikawa Y., Akiyama F., Iwase T., Ogata E., Ehata S., Miyazono K., Imamura T. Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway. Oncogene 27:6322-6333(2008) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_9U31
|
Encyclopedic resources |
Wikidata; Q54904593
|
Entry history |
Entry creation | 23-Feb-2016 |
Last entry update | 19-Dec-2024 |
Version number | 18 |
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