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Cellosaurus HeLa ICRP FLIP-L-mCherry (CVCL_9U01)

[Text version]
Cell line name HeLa ICRP FLIP-L-mCherry
Accession CVCL_9U01
Resource Identification Initiative To cite this cell line use: HeLa ICRP FLIP-L-mCherry (RRID:CVCL_9U01)
Comments Population: African American.
Genetic integration: Method=Transfection/transduction; Gene=Initiator caspase reporter protein (IC-RP). FRET donor-acceptor pair (CFP and YFP) connected by a caspase cleavage sequence ('DEVDR') linker.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1876; CFLAR (Note=Isoform FLIP-L).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; ZERB6; mCherry (Note=Red fluorescent protein derived from drFP583 (dsRed)).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9T98 (HeLa ICRP)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=25953765; DOI=10.15252/msb.20145584; PMCID=PMC4461398
Roux J., Hafner M., Bandara S., Sims J.J., Hudson H., Chai D., Sorger P.K.
Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold.
Mol. Syst. Biol. 11:803-803(2015)

Cross-references
Cell line databases/resources CLO; CLO_0009929
LINCS_HMS; 51103
LINCS_LDP; LCL-2099
Encyclopedic resources Wikidata; Q54882532
Entry history
Entry creation23-Feb-2016
Last entry update19-Dec-2024
Version number14