ID   VACO 703
AC   CVCL_9T33
SY   Vaco 703; VACO703; Vaco703; V703
DR   cancercelllines; CVCL_9T33
DR   GEO; GSM1448108
DR   IARC_TP53; 9388
DR   Wikidata; Q54992783
RX   PubMed=7761852;
RX   PubMed=9715273;
RX   PubMed=11314036;
RX   PubMed=25926053;
CC   Microsatellite instability: Instable (MSI) (PubMed=25926053).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly374Valfs*48 (c.1121delG) (Lys373fs); ClinVar=VCV000237940; Zygosity=Heterozygous (PubMed=9715273).
CC   Omics: Transcriptome analysis by microarray.
ST   Source(s): PubMed=25926053
ST   Amelogenin: X
ST   CSF1PO: 9,12
ST   D13S317: 9,12
ST   D16S539: 9
ST   D21S11: 29.2,31
ST   D5S818: 13
ST   D7S820: 11
ST   TH01: 9,9.3
ST   TPOX: 7,10
ST   vWA: 18,21
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 23-02-16; Last updated: 19-12-24; Version: 11
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RX   PubMed=7761852; DOI=10.1126/science.7761852;
RA   Markowitz S.D., Wang J., Myeroff L.L., Parsons R., Sun L.-Z.,
RA   Lutterbaugh J.D., Fan R.S., Zborowska E., Kinzler K.W., Vogelstein B.,
RA   Brattain M.G., Willson J.K.V.;
RT   "Inactivation of the type II TGF-beta receptor in colon cancer cells
RT   with microsatellite instability.";
RL   Science 268:1336-1338(1995).
//
RX   PubMed=9715273; DOI=10.1038/sj.onc.1201986;
RA   Eshleman J.R., Casey G., Kochera M.E., Sedwick W.D., Swinler S.E.,
RA   Veigl M.L., Willson J.K.V., Schwartz S., Markowitz S.D.;
RT   "Chromosome number and structure both are markedly stable in RER
RT   colorectal cancers and are not destabilized by mutation of p53.";
RL   Oncogene 17:719-725(1998).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L.,
RA   Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R.,
RA   Minna J.D.;
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//