ID   NHEK/SV3
AC   CVCL_9Q50
DR   Evercyte; CLT-011-0026
DR   Wikidata; Q54930513
RX   PubMed=28776197;
WW   Provider; Evercyte; CLT-011-0026; https://web.archive.org/web/20150302212441/http://www.evercyte.com:80/medizin/cell-lines/immortalized-human-somatic-cells/nhek-sv3.html
CC   Senescence: SV40-transformed but with a finite life span (maximum PDL is 30) (Evercyte=CLT-011-0026).
CC   Doubling time: ~48 hours (Evercyte=CLT-011-0026).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Discontinued: Evercyte; CLT-011-0026; true.
CC   Derived from site: In situ; Abdomen, skin, epidermis; UBERON=UBERON_0001416+UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Finite cell line
DT   Created: 23-02-16; Last updated: 10-04-25; Version: 13
//
RX   PubMed=28776197; DOI=10.1007/s00204-017-2034-6; PMCID=PMC5773649;
RA   Weinmuellner R., Kryeziu K., Zbiral B., Tav K., Schoenhacker-Alte B.,
RA   Groza D., Wimmer L.R., Schosserer M., Nagelreiter F., Rosinger S.,
RA   Mildner M., Tschachler E., Grusch M., Grillari J., Heffeter P.;
RT   "Long-term exposure of immortalized keratinocytes to arsenic induces
RT   EMT, impairs differentiation in organotypic skin models and mimics
RT   aspects of human skin derangements.";
RL   Arch. Toxicol. 92:181-194(2018).
//