ID   SAML-2
AC   CVCL_9998
DR   ATCC; CRL-2840
DR   cancercelllines; CVCL_9998
DR   Cosmic; 975298
DR   SKY/M-FISH/CGH; 2854
DR   Wikidata; Q54952089
RX   PubMed=12759925;
RX   PubMed=14671638;
RX   PubMed=29533902;
CC   Characteristics: CSF2 dependent.
CC   Sequence variation: Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (PubMed=12759925).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (PubMed=12759925).
CC   Donor information: Originally the patient was suffering from Hodgkin lymphoma.
CC   Discontinued: ATCC; CRL-2840; true.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): ATCC=CRL-2840
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 11,12
ST   D16S539: 9
ST   D5S818: 11
ST   D7S820: 8,11
ST   TH01: 7,9
ST   TPOX: 11
ST   vWA: 17,19
DI   NCIt; C8252; Therapy-related acute myeloid leukemia
DI   ORDO; Orphanet_86846; Therapy related acute myeloid leukemia and myelodysplastic syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   42Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 17
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RX   PubMed=12759925; DOI=10.1002/gcc.10200;
RA   Knutsen T., Pack S., Petropavlovskaja M., Padilla-Nash H.M.,
RA   Knight C., Mickley L.A., Ried T., Elwood P.C., Roberts S.J.;
RT   "Cytogenetic, spectral karyotyping, fluorescence in situ
RT   hybridization, and comparative genomic hybridization characterization
RT   of two new secondary leukemia cell lines with 5q deletions, and MYC
RT   and MLL amplification.";
RL   Genes Chromosomes Cancer 37:270-281(2003).
//
RX   PubMed=14671638; DOI=10.1038/sj.leu.2403236;
RA   Drexler H.G., Quentmeier H., MacLeod R.A.F.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   MLL gene alterations.";
RL   Leukemia 18:227-232(2004).
//
RX   PubMed=29533902; DOI=10.1515/hsz-2017-0321;
RA   Drexler H.G., Pommerenke C., Eberth S., Nagel S.;
RT   "Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";
RL   Biol. Chem. 399:511-523(2018).
//