AC   CVCL_9997
DR   ATCC; CRL-2776
DR   BioSample; SAMN03151985
DR   cancercelllines; CVCL_9997
DR   Wikidata; Q54952088
RX   PubMed=12759925;
RX   PubMed=29533902;
CC   Problematic cell line: Contaminated. Shown to be a U-937 derivative. Originally thought to originate from a bone marrow aspirate from a 50 year old male patient suffering from a secondary acute myelogenous leukemia (AML) following Hodgkin's disease.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00424.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Discontinued: ATCC; CRL-2776; true.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): ATCC
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 10,12
ST   D16S539: 12
ST   D5S818: 12
ST   D7S820: 9,11
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 14,15
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0007 ! U-937
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 26
RX   PubMed=12759925; DOI=10.1002/gcc.10200;
RA   Knutsen T., Pack S., Petropavlovskaja M., Padilla-Nash H.M.,
RA   Knight C., Mickley L.A., Ried T., Elwood P.C., Roberts S.J.;
RT   "Cytogenetic, spectral karyotyping, fluorescence in situ
RT   hybridization, and comparative genomic hybridization characterization
RT   of two new secondary leukemia cell lines with 5q deletions, and MYC
RT   and MLL amplification.";
RL   Genes Chromosomes Cancer 37:270-281(2003).
RX   PubMed=29533902; DOI=10.1515/hsz-2017-0321;
RA   Drexler H.G., Pommerenke C., Eberth S., Nagel S.;
RT   "Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";
RL   Biol. Chem. 399:511-523(2018).