ID   ZK-58
AC   CVCL_9920
SY   ZK58; HOS 58
DR   cancercelllines; CVCL_9920
DR   Cosmic; 1529906
DR   GEO; GSM879224
DR   IARC_TP53; 27033
DR   Progenetix; CVCL_9920
DR   Wikidata; Q54995932
RX   PubMed=9674117;
RX   PubMed=12645653;
RX   PubMed=15150091;
RX   PubMed=19787792;
RX   PubMed=21519327;
RX   PubMed=23144859;
CC   Characteristics: Established from a nude mice xenograft (PubMed=9674117).
CC   Doubling time: ~72 hours (PubMed=21519327).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=19787792).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Bone, leg; UBERON=UBERON_0005893.
ST   Source(s): PubMed=19787792
ST   Amelogenin: X,Y
ST   D16S539: 11
ST   D18S51: 15,18
ST   D19S433: 12,14
ST   D21S11: 29,30.2
ST   D2S1338: 25
ST   D3S1358: 16
ST   D5S818: 11
ST   D8S1179: 13,14
ST   FGA: 24
ST   SE33: 24.2
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   21Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-09-24; Version: 17
//
RX   PubMed=9674117; DOI=10.1046/j.1432-0436.1998.6320081.x;
RA   Siggelkow H., Niedhart C., Kurre W., Ihbe A., Schulz A.,
RA   Atkinson M.J., Hufner M.;
RT   "In vitro differentiation potential of a new human osteosarcoma cell
RT   line (HOS 58).";
RL   Differentiation 63:81-91(1998).
//
RX   PubMed=12645653; DOI=10.1016/S0165-4608(02)00685-4;
RA   Ozaki T., Neumann T., Wai D.H., Schaefer K.-L., van Valen F., Lindner N.,
RA   Scheel C., Boecker W., Winkelmann W., Dockhorn-Dworniczak B., Horst J.,
RA   Poremba C.;
RT   "Chromosomal alterations in osteosarcoma cell lines revealed by
RT   comparative genomic hybridization and multicolor karyotyping.";
RL   Cancer Genet. Cytogenet. 140:145-152(2003).
//
RX   PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809;
RA   Schaefer K.-L., Brachwitz K., Wai D.H., Braun Y., Diallo R.,
RA   Korsching E., Eisenacher M., Voss R., van Valen F., Baer C., Selle B.,
RA   Spahn L., Liao S.-K., Lee K.A.W., Hogendoorn P.C.W., Reifenberger G.,
RA   Gabbert H.E., Poremba C.;
RT   "Expression profiling of t(12;22) positive clear cell sarcoma of soft
RT   tissue cell lines reveals characteristic up-regulation of potential
RT   new marker genes including ERBB3.";
RL   Cancer Res. 64:3395-3405(2004).
//
RX   PubMed=19787792; DOI=10.1002/gcc.20717;
RA   Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S.E.,
RA   Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H.,
RA   Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W.,
RA   Buerger H., Aigner T., Gabbert H.E., Poremba C.;
RT   "Molecular characterization of commonly used cell lines for bone tumor
RT   research: a trans-European EuroBoNet effort.";
RL   Genes Chromosomes Cancer 49:40-51(2010).
//
RX   PubMed=21519327; DOI=10.1038/labinvest.2011.72;
RA   Mohseny A.B., Machado I., Cai Y.-P., Schaefer K.-L., Serra M.,
RA   Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.;
RT   "Functional characterization of osteosarcoma cell lines provides
RT   representative models to study the human disease.";
RL   Lab. Invest. 91:1195-1205(2011).
//
RX   PubMed=23144859; DOI=10.1371/journal.pone.0048262; PMCID=PMC3492335;
RA   Kresse S.H., Rydbeck H., Skarn M., Namlos H.M., Barragan-Polania A.H.,
RA   Cleton-Jansen A.-M., Serra M., Liestol K., Hogendoorn P.C.W., Hovig E.,
RA   Myklebost O., Meza-Zepeda L.A.;
RT   "Integrative analysis reveals relationships of genetic and epigenetic
RT   alterations in osteosarcoma.";
RL   PLoS ONE 7:E48262-E48262(2012).
//