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Cellosaurus FB-2 (CVCL_9917)

[Text version]
Cell line name FB-2
Synonyms FB2
Accession CVCL_9917
Resource Identification Initiative To cite this cell line use: FB-2 (RRID:CVCL_9917)
Comments Problematic cell line: Contaminated. Shown to be a TPC-1 derivative (PubMed=19087340; PubMed=20143388). Originally thought to originate from a 36 year old female patient with a well-differentiated thyroid papillary carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00200.
Population: Japanese.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Gene fusion; HGNC; HGNC:18782; CCDC6 + HGNC; HGNC:9967; RET; Name(s)=CCDC6-RET, RET/PTC1 (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ala68fs (c.204_208delGGAGC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Gln1089Ter (c.3265C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (from parent cell line).
Disease Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6298 (TPC-1)
Sex of cell Female
Age at sampling Adult
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=11807785; DOI=10.1002/ijc.10116
Basolo F., Giannini R., Toniolo A., Casalone R., Nikiforova M., Pacini F., Elisei R., Miccoli P., Berti P., Faviana P., Fiore L., Monaco C., Pierantoni G.M., Fedele M., Nikiforov Y.E., Santoro M.M., Fusco A.
Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement.
Int. J. Cancer 97:608-614(2002)

PubMed=17725429; DOI=10.1089/thy.2007.0097
Meireles A.M., Preto A., Rocha A.S., Rebocho A.P., Maximo V., Pereira-Castro I., Moreira S., Feijao T., Botelho T., Marques R., Trovisco V., Cirnes L., Alves C., Velho S., Soares P., Sobrinho-Simoes M.
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.
Thyroid 17:707-715(2007)

PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892
Ribeiro F.R., Meireles A.M., Rocha A.S., Teixeira M.R.
Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.
BMC Cancer 8:371.1-371.11(2008)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151972
Encyclopedic resources Wikidata; Q54833256
Polymorphism and mutation databases Cosmic; 1084278
IARC_TP53; 25010
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number25