ID   XTC.UC1
AC   CVCL_9916
SY   XTC-UC1; XTC-1; XTC1; XTC
DR   cancercelllines; CVCL_9916
DR   Cosmic; 1084281
DR   Cosmic; 1162844
DR   Cosmic; 2036689
DR   Cosmic; 2328761
DR   Wikidata; Q54995073
RX   PubMed=9669284;
RX   PubMed=11349830;
RX   PubMed=16646677;
RX   PubMed=16778181;
RX   PubMed=17725429;
RX   PubMed=19087340;
RX   PubMed=26354775;
RX   PubMed=29066502;
RX   PubMed=31443247;
RX   PubMed=36599897;
CC   Characteristics: Has a near-homozygous genome (NHG) (PubMed=29066502).
CC   Doubling time: 103 +- 6.7 hours (PubMed=9669284).
CC   Sequence variation: Mutation; HGNC; HGNC:7427; MT-CYB; Simple; p.Glu271Lys (m.15557G>A); ClinVar=VCV000693906; Zygosity=Heteroplasmic; Note=In 70.3% (PubMed=16778181).
CC   Sequence variation: Mutation; HGNC; HGNC:7455; MT-ND1; Simple; p.Gly101Ter (m.3571insC); Zygosity=Heteroplasmic; Note=In 94.3% (PubMed=16778181).
CC   Sequence variation: Mutation; HGNC; HGNC:8607; PRKN; Simple; p.Val380Leu (c.1138G>C); ClinVar=VCV000041221; Zygosity=Homozygous; Note=Germline (PubMed=26354775).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro151Thr (c.451C>A); ClinVar=VCV000012369; Zygosity=Homozygous (PubMed=31443247).
CC   Omics: Genomics; Mitochondrial genome sequencing.
CC   Omics: Metabolomics.
CC   Miscellaneous: STR profile from personal communication of Marlow, Laura A.
CC   Derived from site: Metastatic; Breast; UBERON=UBERON_0000310.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12
ST   D18S51: 13,17
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 12
ST   FGA: 24.2
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 18
DI   NCIt; C4946; Thyroid gland Hurthle cell carcinoma
DI   ORDO; Orphanet_146; Differentiated thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 24
//
RX   PubMed=16778181; DOI=10.1158/0008-5472.CAN-06-0171;
RA   Bonora, Elena
RA   Porcelli, Anna Maria
RA   Gasparre, Giuseppe
RA   Biondi, Annalisa
RA   Ghelli, Anna
RA   Carelli, Valerio
RA   Baracca, Alessandra
RA   Tallini, Giovanni
RA   Martinuzzi, Andrea
RA   Lenaz, Giorgio
RA   Rugolo, Michela
RA   Romeo, Giovanni
RT   "Defective oxidative phosphorylation in thyroid oncocytic carcinoma is
RT   associated with pathogenic mitochondrial DNA mutations affecting
RT   complexes I and III.";
RL   Cancer Res. 66:6087-6096(2006).
//
RX   PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892;
RA   Ribeiro, Franclim Ricardo
RA   Meireles, Ana Margarida
RA   Rocha, Ana Sofia
RA   Teixeira, Manuel R.
RT   "Conventional and molecular cytogenetics of human non-medullary
RT   thyroid carcinoma: characterization of eight cell line models and
RT   review of the literature on clinical samples.";
RL   BMC Cancer 8:371.1-371.11(2008).
//
RX   PubMed=16646677; DOI=10.1089/thy.2006.16.325;
RA   Stankov, Karmen
RA   Biondi, Annalisa
RA   D'Aurelio, Marilena
RA   Gasparre, Giuseppe
RA   Falasca, Anna
RA   Romeo, Giovanni
RA   Lenaz, Giorgio
RT   "Mitochondrial activities of a cell line derived from thyroid Hurthle
RT   cell tumors.";
RL   Thyroid 16:325-331(2006).
//
RX   PubMed=26354775; DOI=10.1093/carcin/bgv122;
RA   Lee, Junguee
RA   Ham, Sujin
RA   Lee, Min Hee
RA   Kim, Soung Jung
RA   Park, Ji Hoon
RA   Lee, Seong Eun
RA   Chang, Joon Young
RA   Joung, Kyong Hye
RA   Kim, Tae Yong
RA   Kim, Jin Man
RA   Sul, Hae Joung
RA   Kweon, Gi Ryang
RA   Jo, Young Suk
RA   Kim, Koon Soon
RA   Shong, Young Kee
RA   Gasparre, Giuseppe
RA   Chung, Jong Kyeong
RA   Porcelli, Anna Maria
RA   Shong, Minho
RT   "Dysregulation of parkin-mediated mitophagy in thyroid Hurthle cell
RT   tumors.";
RL   Carcinogenesis 36:1407-1418(2015).
//
RX   PubMed=29066502; DOI=10.1530/ERC-17-0288;
RA   Corver, Willem E.
RA   Demmers, Joris
RA   Oosting, Jan
RA   Sahraeian, Shima
RA   Boot, Arnoud
RA   Ruano, Dina
RA   van Wezel, Tom
RA   Morreau, Hans
RT   "ROS-induced near-homozygous genomes in thyroid cancer.";
RL   Endocr. Relat. Cancer 25:83-97(2018).
//
RX   PubMed=31443247; DOI=10.3390/cancers11081185; PMCID=PMC6721552;
RA   Aydemirli, Mehtap Derya
RA   Corver, Willem E.
RA   Beuk, Ruben
RA   Roepman, Paul
RA   Solleveld-Westerink, Nienke
RA   van Wezel, Tom
RA   Kapiteijn, Ellen H.W.
RA   Morreau, Hans
RT   "Targeted treatment options of recurrent radioactive iodine refractory
RT   Hurthle cell cancer.";
RL   Cancers (Basel) 11:1185.1-1185.16(2019).
//
RX   PubMed=11349830; DOI=10.1089/10507250152039055;
RA   Savagner, Frederique
RA   Chevrollier, Arnaud
RA   Loiseau, Dominique
RA   Morgan, Claudia
RA   Reynier, Pascal
RA   Clark, Orlo Herrick
RA   Stepien, Georges
RA   Malthiery, Yves
RT   "Mitochondrial activity in XTC.UC1 cells derived from thyroid
RT   oncocytoma.";
RL   Thyroid 11:327-333(2001).
//
RX   PubMed=36599897; DOI=10.1038/s41598-023-27461-2; PMCID=PMC9813134;
RA   Kurashige, Tomomi
RA   Shimamura, Mika
RA   Hamada, Koichiro
RA   Matsuse, Michiko
RA   Mitsutake, Norisato
RA   Nagayama, Yuji
RT   "Characterization of metabolic reprogramming by metabolomics in the
RT   oncocytic thyroid cancer cell line XTC.UC1.";
RL   Sci. Rep. 13:149.1-149.11(2023).
//
RX   PubMed=17725429; DOI=10.1089/thy.2007.0097;
RA   Meireles, Ana Margarida
RA   Preto, Ana
RA   Rocha, Ana Sofia
RA   Rebocho, Ana Paula
RA   Maximo, Valdemar
RA   Pereira-Castro, Isabel
RA   Moreira, Severina
RA   Feijao, Talia
RA   Botelho, Tiago
RA   Marques, Ricardo
RA   Trovisco, Vitor
RA   Cirnes, Luis
RA   Alves, Cintia
RA   Velho, Sergia
RA   Soares, Paula
RA   Sobrinho-Simoes, Manuel
RT   "Molecular and genotypic characterization of human thyroid follicular
RT   cell carcinoma-derived cell lines.";
RL   Thyroid 17:707-715(2007).
//
RX   PubMed=9669284; DOI=10.1089/thy.1998.8.475;
RA   Zielke, Andreas
RA   Tezelman, Serdar
RA   Jossart, Gregg H.
RA   Wong, Mariwil G.
RA   Siperstein, Allan E.
RA   Duh, Quan-Yang
RA   Clark, Orlo Herrick
RT   "Establishment of a highly differentiated thyroid cancer cell line of
RT   Hurthle cell origin.";
RL   Thyroid 8:475-483(1998).
//