ID   UKF-NB-3
AC   CVCL_9904
SY   UKF-NB3
DR   IARC_TP53; 26506
DR   Wikidata; Q54990311
RX   CelloPub=CLPUB00123;
RX   PubMed=8949988;
RX   PubMed=9201287;
RX   PubMed=16142320;
RX   PubMed=16151587;
RX   PubMed=17505515;
RX   PubMed=19147553;
RX   PubMed=22170099;
RX   PubMed=22476102;
RX   PubMed=24466371;
RX   PubMed=25749379;
RX   PubMed=27517323;
RX   PubMed=27735941;
RX   PubMed=31581737;
CC   Doubling time: 22 +- 1.9 hours (PubMed=16142320).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): PubMed=31581737
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11
ST   D16S539: 13
ST   D18S51: 16,18
ST   D19S433: 14
ST   D21S11: 29,33.2
ST   D2S1338: 16,21
ST   D3S1358: 15,18
ST   D5S818: 11
ST   D7S820: 10,11
ST   D8S1179: 9,10
ST   FGA: 19,25
ST   Penta D: 8,15
ST   Penta E: 12
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 15,18
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 14
//
RX   CelloPub=CLPUB00123;
RA   Cinatl, Jaroslaw
RA   Gussetis, Evgenios S.
RA   Cinatl, Jindrich Jr.
RA   Ebener, Uwe
RA   Mainke, Marion
RA   Schwabe, Dirk
RA   Doerr, Hans-Wilhelm
RA   Kornhuber, Bernhard
RA   Gerein, Valentin
RT   "Differentiation arrest in neuroblastoma cell culture.";
RL   J. Cancer Res. Clin. Oncol. 116 Suppl. 1:9-9(1990).
//
RX   PubMed=8949988; DOI=10.1097/00001813-199609000-00008;
RA   Cinatl, Jindrich Jr.
RA   Cinatl, Jaroslaw
RA   Scholz, Martin
RA   Hernaiz Driever, Pablo
RA   Henrich, Dirk
RA   Kabickova, Hanka
RA   Vogel, Jens-Uwe
RA   Doerr, Hans-Wilhelm
RA   Kornhuber, Bernhard
RT   "Antitumor activity of sodium valproate in cultures of human
RT   neuroblastoma cells.";
RL   Anticancer Drugs 7:766-773(1996).
//
RX   PubMed=9201287;
RA   Cinatl, Jindrich Jr.
RA   Hernaiz Driever, Pablo
RA   Cinatl, Jaroslaw
RA   Ruckert, Dieter G.
RA   Gumbel, Hermann O.C.
RA   Rabenau, Holger F.
RA   Kornhuber, Bernhard
RA   Doerr, Hans-Wilhelm
RT   "Increased efficacy of aphidicolin killing of human neuroblastoma
RT   cells in vitro by encapsulation in liposomes.";
RL   Neoplasma 44:91-95(1997).
//
RX   PubMed=16142320; DOI=10.3892/ijo.27.4.1029;
RA   Kotchetkov, Rouslan
RA   Hernaiz Driever, Pablo
RA   Cinatl, Jaroslaw
RA   Michaelis, Martin
RA   Karaskova, Jana
RA   Blaheta, Roman A.
RA   Squire, Jeremy Andrew
RA   von Deimling, Andreas
RA   Moog, Jussi
RA   Cinatl, Jindrich Jr.
RT   "Increased malignant behavior in neuroblastoma cells with acquired
RT   multi-drug resistance does not depend on P-gp expression.";
RL   Int. J. Oncol. 27:1029-1037(2005).
//
RX   PubMed=16151587;
RA   Bedrnicek, Jiri B.
RA   Vicha, Ales
RA   Jarosova, Marie
RA   Holzerova, Milena
RA   Cinatl, Jindrich Jr.
RA   Michaelis, Martin
RA   Cinatl, Jaroslaw
RA   Eckschlager, Tomas
RT   "Characterization of drug-resistant neuroblastoma cell lines by
RT   comparative genomic hybridization.";
RL   Neoplasma 52:415-419(2005).
//
RX   PubMed=17505515; DOI=10.1038/sj.bjc.6603777; PMCID=PMC2359931;
RA   Blaheta, Roman A.
RA   Michaelis, Martin
RA   Natsheh, Iyad
RA   Hasenberg, Christoph
RA   Weich, Eva
RA   Relja, Borna
RA   Jonas, Dietger
RA   Doerr, Hans-Wilhelm
RA   Cinatl, Jindrich Jr.
RT   "Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant
RT   neuroblastoma tumour cells to endothelium.";
RL   Br. J. Cancer 96:1699-1706(2007).
//
RX   PubMed=19147553; DOI=10.1158/0008-5472.CAN-08-1856;
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Klassert, Denise
RA   von Deimling, Andreas
RA   Weber, Kristoffer
RA   Fehse, Boris
RA   Kammerer, Bernd
RA   Doerr, Hans-Wilhelm
RA   Cinatl, Jindrich Jr.
RT   "Reversal of P-glycoprotein-mediated multidrug resistance by the
RT   murine double minute 2 antagonist nutlin-3.";
RL   Cancer Res. 69:416-421(2009).
//
RX   PubMed=22170099; DOI=10.1038/cddis.2011.129; PMCID=PMC3252738;
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Barth, Susanne
RA   Cinatl, Jaroslaw
RA   van Rikxoort, Marijke
RA   Loschmann, Nadine
RA   Voges, Yvonne
RA   Breitling, Rainer
RA   von Deimling, Andreas
RA   Rodel, Franz
RA   Weber, Kristoffer
RA   Fehse, Boris
RA   Mack, Elisabeth
RA   Stiewe, Thorsten
RA   Doerr, Hans-Wilhelm
RA   Speidel, Daniel
RA   Cinatl, Jindrich Jr.
RT   "Adaptation of cancer cells from different entities to the MDM2
RT   inhibitor nutlin-3 results in the emergence of p53-mutated
RT   multi-drug-resistant cancer cells.";
RL   Cell Death Dis. 2:e243.1-e243.8(2011).
//
RX   PubMed=22476102; DOI=10.1038/cddis.2012.35; PMCID=PMC3358013;
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Agha, Bishr
RA   Barth, Susanne
RA   Voges, Yvonne
RA   Loschmann, Nadine
RA   von Deimling, Andreas
RA   Breitling, Rainer
RA   Doerr, Hans-Wilhelm
RA   Rodel, Franz
RA   Speidel, Daniel
RA   Cinatl, Jindrich Jr.
RT   "Human neuroblastoma cells with acquired resistance to the p53
RT   activator RITA retain functional p53 and sensitivity to other p53
RT   activating agents.";
RL   Cell Death Dis. 3:e294.1-e294.8(2012).
//
RX   PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703;
RA   Loschmann, Nadine
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Zehner, Richard
RA   Cinatl, Jaroslaw
RA   Voges, Yvonne
RA   Sharifi, Mohsen
RA   Riecken, Kristoffer
RA   Meyer, Jochen
RA   von Deimling, Andreas
RA   Fichtner, Iduna
RA   Ghafourian, Taravat
RA   Westermann, Frank
RA   Cinatl, Jindrich Jr.
RT   "Testing of SNS-032 in a panel of human neuroblastoma cell lines with
RT   acquired resistance to a broad range of drugs.";
RL   Transl. Oncol. 6:685-696(2013).
//
RX   PubMed=25749379; DOI=10.18632/oncotarget.2889; PMCID=PMC4627332;
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Loschmann, Nadine
RA   Sharifi, Mohsen
RA   Ghafourian, Taravat
RA   Cinatl, Jindrich Jr.
RT   "Enzastaurin inhibits ABCB1-mediated drug efflux independently of
RT   effects on protein kinase C signalling and the cellular p53 status.";
RL   Oncotarget 6:17605-17620(2015).
//
RX   PubMed=27517323; DOI=10.18632/oncotarget.11160; PMCID=PMC5295411;
RA   Loschmann, Nadine
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Voges, Yvonne
RA   Balonova, Barbora
RA   Blight, Barry A.
RA   Cinatl, Jindrich Jr.
RT   "ABCB1 as predominant resistance mechanism in cells with acquired
RT   SNS-032 resistance.";
RL   Oncotarget 7:58051-58064(2016).
//
RX   PubMed=27735941; DOI=10.1038/cddis.2016.257; PMCID=PMC5133961;
RA   Voges, Yvonne
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Schaller, Torsten
RA   Schneider, Constanze
RA   Politt, Katharina
RA   Mernberger, Marco
RA   Nist, Andrea
RA   Stiewe, Thorsten
RA   Wass, Mark N.
RA   Rodel, Franz
RA   Cinatl, Jindrich Jr.
RT   "Effects of YM155 on survivin levels and viability in neuroblastoma
RT   cells with acquired drug resistance.";
RL   Cell Death Dis. 7:e2410.1-e2410.11(2016).
//
RX   PubMed=31581737; DOI=10.3390/cells8101194; PMCID=PMC6830094;
RA   Povey, Jane F.
RA   Saintas, Emily
RA   Aderemi, Adewale Victor
RA   Rothweiler, Florian
RA   Zehner, Richard
RA   Dirks, Wilhelm Gerhard
RA   Cinatl, Jindrich Jr.
RA   Racher, Andrew J.
RA   Wass, Mark N.
RA   Smales, Christopher Mark
RA   Michaelis, Martin
RT   "Intact-cell MALDI-ToF mass spectrometry for the authentication of
RT   drug-adapted cancer cell lines.";
RL   Cells 8:1194.1-1194.12(2019).
//