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Cellosaurus HepG2-DM2 (CVCL_9874)

[Text version]
Cell line name HepG2-DM2
Accession CVCL_9874
Resource Identification Initiative To cite this cell line use: HepG2-DM2 (RRID:CVCL_9874)
Comments Population: Caucasian.
Virology: Transfected with a hepatitis B virus (HBV) subtype adr genome with a DNA polymerase having p.Leu526Met and p.Met550Val mutations (PubMed=11083647).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=11083647; DOI=10.1128/AAC.44.12.3402-3407.2000; PMCID=PMC90212
Fu L., Cheng Y.-C.
Characterization of novel human hepatoma cell lines with stable hepatitis B virus secretion for evaluating new compounds against lamivudine- and penciclovir-resistant virus.
Antimicrob. Agents Chemother. 44:3402-3407(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9874
Encyclopedic resources Wikidata; Q54882849
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number20