Cellosaurus cell line OCUT-2 (CVCL

Cellosaurus OCUT-2 (CVCL_9814)

[Text version]

Cell line name

OCUT-2

Synonyms

OCUT2; Osaka City University Thyroid-2

Accession

CVCL_9814

Resource Identification Initiative

To cite this cell line use: OCUT-2 (RRID:CVCL_9814)

Comments

Population: Japanese.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=24357248; PubMed=30737244).
Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (PubMed=24357248).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Homozygous; Note=In promoter (PubMed=30737244).

Disease

Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_W915 (OCUT-2C)

Sex of cell

Female

Age at sampling

81Y

Category

Cancer cell line

STR profile

Source(s): JCRB=JCRB1870; PubMed=30737244

Markers:

Amelogenin	X
CSF1PO	11
D3S1358	15
D5S818	13
D7S820	11
D8S1179	13,14
D13S317	11
D16S539	9
D18S51	13
D21S11	30,32.2
FGA	21,26
TH01	6,7
TPOX	11
vWA	14,18

Publications

PubMed=15785737; DOI=10.1038/sj.bjc.6602461; PMCID=PMC2361935
Nobuhara Y., Onoda N., Yamashita Y., Yamasaki M., Ogisawa K., Takashima T., Ishikawa T., Hirakawa K.
Efficacy of epidermal growth factor receptor-targeted molecular therapy in anaplastic thyroid cancer cell lines.
Br. J. Cancer 92:1110-1116(2005)

PubMed=24357248; DOI=10.1007/s00268-013-2409-7
Onoda N., Nakamura M., Aomatsu N., Noda S., Kashiwagi S., Hirakawa K.
Establishment, characterization and comparison of seven authentic anaplastic thyroid cancer cell lines retaining clinical features of the original tumors.
World J. Surg. 38:688-695(2014)

PubMed=26137260; DOI=10.3892/mco.2015.496; PMCID=PMC4471583
Onoda N., Nakamura M., Aomatsu N., Noda S., Kashiwagi S., Kurata K., Uchino S., Hirakawa K.
Significant cytostatic effect of everolimus on a gefitinib-resistant anaplastic thyroid cancer cell line harboring PI3KCA gene mutation.
Mol. Clin. Oncol. 3:522-526(2015)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references

Cell line collections (Providers)

JCRB; JCRB1870

Cell line databases/resources

cancercelllines; CVCL_9814

Anatomy/cell type resources

BTO; BTO_0005143

Encyclopedic resources

Wikidata; Q54931846

Polymorphism and mutation databases

Cosmic; 1507373
Cosmic; 1533549
Cosmic; 1536126
Cosmic; 1889004
Cosmic; 2791082

Entry history

Entry creation

06-Jun-2012

Last entry update

19-Dec-2024

Version number