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Cellosaurus Tet21N (CVCL_9812)

[Text version]
Cell line name Tet21N
Synonyms TET21/N; Tet21/N; Tet-21/N; SHEP-21/N; SHEP-21N; SHEP21N
Accession CVCL_9812
Resource Identification Initiative To cite this cell line use: Tet21N (RRID:CVCL_9812)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 7559; MYCN.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2A38 (SHEP-SF)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Publications

PubMed=8761302
Lutz W., Stohr M., Schurmann J., Wenzel A., Lohr A., Schwab M.
Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.
Oncogene 13:803-812(1996)

PubMed=17506115; DOI=10.1002/nbm.1181
Peet A.C., McConville C.M., Wilson M.P., Levine B.A., Reed M., Dyer S.A., Edwards E.C., Strachan M.C., McMullan D.J., Wilkes T.M., Grundy R.G.
1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines.
NMR Biomed. 20:692-700(2007)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9812
Anatomy/cell type resources BTO; BTO:0004654
Encyclopedic resources Wikidata; Q54972195
Gene expression databases GEO; GSM692858
Entry history
Entry creation06-Jun-2012
Last entry update10-Sep-2024
Version number21