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Cellosaurus DKO-1 (CVCL_9798)

[Text version]
Cell line name DKO-1
Synonyms DKO1
Accession CVCL_9798
Resource Identification Initiative To cite this cell line use: DKO-1 (RRID:CVCL_9798)
Comments Population: Caucasian.
Characteristics: In DLD-1 one of the two KRAS alleles has a p.Gly13Asp mutation. This cell line is KO for the normal allele.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:6407; KRAS (Note=1 of 2 alleles).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0248 (DLD-1)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=8465203; DOI=10.1126/science.8465203
Shirasawa S., Furuse M., Yokoyama N., Sasazuki T.
Altered growth of human colon cancer cell lines disrupted at activated Ki-ras.
Science 260:85-88(1993)

Cross-references
Cell line databases/resources TOKU-E; 4094
Encyclopedic resources Wikidata; Q54831119
Experimental variables resources EFO; EFO_0022522
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number14