Cell line name |
HKe-3 |
Synonyms |
HKE-3; Hke-3; HKE3; Hke3 |
Accession |
CVCL_9796 |
Resource Identification Initiative |
To cite this cell line use: HKe-3 (RRID:CVCL_9796) |
Comments |
Population: Caucasian. Characteristics: In HCT 116 one of the two KRAS alleles has a p.Gly13Asp mutation. This cell line is KO for the mutant allele. Knockout cell: Method=Homologous recombination; HGNC; HGNC:6407; KRAS (Note=1 of 2 alleles). Omics: Transcriptome analysis by RNAseq. Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon carcinoma (NCIt: C4910) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0291 (HCT 116) |
Sex of cell |
Male |
Age at sampling |
48Y |
Category |
Cancer cell line |
Publications | PubMed=8465203; DOI=10.1126/science.8465203 Shirasawa S., Furuse M., Yokoyama N., Sasazuki T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 260:85-88(1993) PubMed=9354428 Ohmori M., Shirasawa S., Furuse M., Okumura K., Sasazuki T. Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells. Cancer Res. 57:4714-4717(1997) PubMed=28192450; DOI=10.1371/journal.pone.0171435; PMCID=PMC5305277 Fasterius E., Raso C., Kennedy S.A., Rauch N., Lundin P., Kolch W., Uhlen M., Al-Khalili Szigyarto C. A novel RNA sequencing data analysis method for cell line authentication. PLoS ONE 12:E0171435-E0171435(2017) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_9796
|
Anatomy/cell type resources |
BTO; BTO_0003469
|
Encyclopedic resources |
Wikidata; Q54889765
|
Experimental variables resources |
EFO; EFO_0022707
|
Entry history |
Entry creation | 06-Jun-2012 |
Last entry update | 19-Dec-2024 |
Version number | 24 |
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