ID   WA07
AC   CVCL_9772
SY   WA 07; WA-07; WA7; H7; H7 GE07; H7-hESC; ES-WA7; WAe002-A; WICELLe002-A; WAe007-A; WA07-PCBC; PCBC02hse2014030501; SC14-066
DR   BTO; BTO:0006061
DR   EFO; EFO_0005904
DR   BioSample; SAMN03471896
DR   ENCODE; ENCBS017AOD
DR   ENCODE; ENCBS052WSJ
DR   ENCODE; ENCBS058YII
DR   ENCODE; ENCBS068KXI
DR   ENCODE; ENCBS291AAA
DR   ENCODE; ENCBS292AAA
DR   ENCODE; ENCBS293AAA
DR   ENCODE; ENCBS297CQV
DR   ENCODE; ENCBS311AAZ
DR   ENCODE; ENCBS336AYE
DR   ENCODE; ENCBS465FZV
DR   ENCODE; ENCBS559YVY
DR   ENCODE; ENCBS611ORI
DR   ENCODE; ENCBS624XJG
DR   ENCODE; ENCBS721YNV
DR   ENCODE; ENCBS851RDN
DR   ENCODE; ENCBS884CKU
DR   ENCODE; ENCBS920PVU
DR   ENCODE; ENCBS962QAF
DR   GEO; GSM347922
DR   GEO; GSM383877
DR   GEO; GSM384099
DR   GEO; GSM499755
DR   GEO; GSM499756
DR   GEO; GSM500935
DR   GEO; GSM510581
DR   GEO; GSM537623
DR   GEO; GSM537639
DR   GEO; GSM537640
DR   GEO; GSM537641
DR   GEO; GSM537657
DR   GEO; GSM580005
DR   GEO; GSM621347
DR   GEO; GSM621353
DR   GEO; GSM637776
DR   GEO; GSM669896
DR   GEO; GSM669926
DR   GEO; GSM736610
DR   GEO; GSM736638
DR   GEO; GSM856730
DR   GEO; GSM862732
DR   GEO; GSM945183
DR   GEO; GSM945184
DR   GEO; GSM945185
DR   GEO; GSM945186
DR   GEO; GSM981283
DR   GEO; GSM1008596
DR   GEO; GSM1022649
DR   GEO; GSM1022656
DR   GEO; GSM1022660
DR   GEO; GSM1022670
DR   GEO; GSM1084991
DR   GEO; GSM1085014
DR   GEO; GSM1215275
DR   GEO; GSM1215276
DR   GEO; GSM1589801
DR   GEO; GSM1589813
DR   GEO; GSM1589933
DR   GEO; GSM1589945
DR   hPSCreg; WAe007-A
DR   IGRhCellID; H7%20p91
DR   ISCR; 88
DR   NIHhESC; NIHhESC-10-0061
DR   SKIP; SKIP001934
DR   WiCell; wa07
DR   WiCell; wa07-pcbc
DR   Wikidata; Q54993513
RX   PubMed=9804556;
RX   PubMed=14745950;
RX   PubMed=15345125;
RX   PubMed=16388305;
RX   PubMed=16919167;
RX   PubMed=17287758;
RX   PubMed=17570852;
RX   PubMed=17572666;
RX   PubMed=21295703;
RX   PubMed=21983960;
RX   PubMed=22315618;
RX   PubMed=23117585;
RX   PubMed=23341440;
RX   PubMed=27293150;
RX   PubMed=27688775;
RX   PubMed=28445466;
RX   PubMed=30388422;
WW   http://genome.ucsc.edu/ENCODE/protocols/cell/human/H7-hESC_StamAndCrawford_protocol.pdf
WW   https://stemcelldb.nih.gov/cellLineDetails.do?id=3
WW   https://news.wisc.edu/nih-reapproves-wicells-h9-and-three-other-wisconsin-stem-cell-lines-for-federally-funded-research/
CC   Part of: ENCODE project common cell types; tier 3.
CC   Part of: NHBLI Progenitor Cell Biology Consortium (PCBC) collection.
CC   From: University of Wisconsin; Madison; USA.
CC   Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0061.
CC   Registration: Swiss research registry; BAG-hES-IMP-0034.
CC   Registration: UK Stem Cell Bank (UKSCB); Steering comm. appl. SCSC06-18/SCSC11-18.
CC   HLA typing: A*02:25; B*18,35; C*04,12; DQB1*02,03; DRB1*07,11; DRB3*02 (PubMed=16919167).
CC   Omics: CTCF ChIP-seq epigenome analysis.
CC   Omics: H3K27me3 ChIP-seq epigenome analysis.
CC   Omics: H3K36me3 ChIP-seq epigenome analysis.
CC   Omics: H3K4me1 ChIP-seq epigenome analysis.
CC   Omics: H3K4me3 ChIP-seq epigenome analysis.
CC   Omics: H3K9ac ChIP-seq epigenome analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep phosphoproteome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Omics: Transcriptome analysis by serial analysis of gene expression (SAGE).
CC   Anecdotal: WA01, WA07, WA09, WA13 and WA14 were the first human embryonic stem cells to be established.
CC   Donor information: Embryo is sibling to those giving rise to WA13 (Cellosaurus=CVCL_9774) and WA14 (Cellosaurus=CVCL_9775).
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
ST   Source(s): PubMed=16919167; WiCell
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11,12
ST   D16S539: 12,13
ST   D5S818: 11,13
ST   D7S820: 10,11
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 14,15
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 33
//
RX   PubMed=9804556; DOI=10.1126/science.282.5391.1145;
RA   Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A.,
RA   Swiergiel J.J., Marshall V.S., Jones J.M.;
RT   "Embryonic stem cell lines derived from human blastocysts.";
RL   Science 282:1145-1147(1998).
//
RX   PubMed=14745950; DOI=10.1002/dvdy.10431;
RA   Carpenter M.K., Rosler E.S., Fisk G.J., Brandenberger R., Ares X.,
RA   Miura T., Lucero M.T., Rao M.S.;
RT   "Properties of four human embryonic stem cell lines maintained in a
RT   feeder-free culture system.";
RL   Dev. Dyn. 229:243-258(2004).
//
RX   PubMed=15345125; DOI=10.1089/scd.2004.13.325;
RA   Draper J.S., Moore H.D., Ruban L.N., Gokhale P.J., Andrews P.W.;
RT   "Culture and characterization of human embryonic stem cells.";
RL   Stem Cells Dev. 13:325-336(2004).
//
RX   PubMed=16388305; DOI=10.1038/nbt1177;
RA   Ludwig T.E., Levenstein M.E., Jones J.M., Berggren W.T., Mitchen E.R.,
RA   Frane J.L., Crandall L.J., Daigh C.A., Conard K.R., Piekarczyk M.S.,
RA   Llanas R.A., Thomson J.A.;
RT   "Derivation of human embryonic stem cells in defined conditions.";
RL   Nat. Biotechnol. 24:185-187(2006).
//
RX   PubMed=16919167; DOI=10.1186/1741-7007-4-28;
RA   Josephson R., Sykes G.R., Liu Y., Ording C.J., Xu W.-N., Zeng X.-M.,
RA   Shin S., Loring J.F., Maitra A., Rao M.S., Auerbach J.M.;
RT   "A molecular scheme for improved characterization of human embryonic
RT   stem cell lines.";
RL   BMC Biol. 4:28.1-28.13(2006).
//
RX   PubMed=17287758; DOI=10.1038/nbt1285;
RA   Baker D.E.C., Harrison N.J., Maltby E., Smith K., Moore H.D., Shaw P.J.,
RA   Heath P.R., Holden H., Andrews P.W.;
RT   "Adaptation to culture of human embryonic stem cells and oncogenesis
RT   in vivo.";
RL   Nat. Biotechnol. 25:207-215(2007).
//
RX   PubMed=17570852; DOI=10.1186/gb-2007-8-6-r113;
RA   Hirst M., Delaney A., Rogers S.A., Schnerch A., Persaud D.R.,
RA   O'Connor M.D., Zeng T., Moksa M., Fichter K., Mah D., Go A.,
RA   Morin R.D., Baross A., Zhao Y.-J., Khattra J., Prabhu A.-L., Pandoh P.,
RA   McDonald H., Asano J.K., Dhalla N., Ma K., Lee S., Ally A., Chahal N.,
RA   Menzies S., Siddiqui A., Holt R.A., Jones S.J.M., Gerhard D.S.,
RA   Thomson J.A., Eaves C.J., Marra M.A.;
RT   "LongSAGE profiling of nine human embryonic stem cell lines.";
RL   Genome Biol. 8:R113.1-R113.12(2007).
//
RX   PubMed=17572666; DOI=10.1038/nbt1318;
RA   Adewumi O., Aflatoonian B., Ahrlund-Richter L., Amit M., Andrews P.W.,
RA   Beighton G., Bello P.A., Benvenisty N., Berry L.S., Bevan S., Blum B.,
RA   Brooking J., Chen K.G., Choo A.B.-H., Churchill G.A., Corbel M.,
RA   Damjanov I., Draper J.S., Dvorak P., Emanuelsson K., Fleck R.A.,
RA   Ford A., Gertow K., Gertsenstein M., Gokhale P.J., Hamilton R.S.,
RA   Hampl A., Healy L.E., Hovatta O., Hyllner J., Imreh M.P.,
RA   Itskovitz-Eldor J., Jackson J., Johnson J.L., Jones M., Kee K.,
RA   King B.L., Knowles B.B., Lako M., Lebrin F., Mallon B.S., Manning D.,
RA   Mayshar Y., McKay R.D.G., Michalska A.E., Mikkola M., Mileikovsky M.,
RA   Minger S.L., Moore H.D., Mummery C.L., Nagy A., Nakatsuji N.,
RA   O'Brien C.M., Oh S.K.-W., Olsson C., Otonkoski T., Park K.-Y.,
RA   Passier R., Patel H., Patel M.J., Pedersen R., Pera M.F.,
RA   Piekarczyk M.S., Reijo Pera R.A., Reubinoff B.E., Robins A.J.,
RA   Rossant J., Rugg-Gunn P., Schulz T.C., Semb H., Sherrer E.S., Siemen H.,
RA   Stacey G.N., Stojkovic M., Suemori H., Szatkiewicz J., Turetsky T.T.,
RA   Tuuri T., van den Brink S., Vintersten K., Vuoristo S.,
RA   Ward-van Oostwaard D., Weaver T.A., Young L.A., Zhang W.-D.;
RT   "Characterization of human embryonic stem cell lines by the
RT   International Stem Cell Initiative.";
RL   Nat. Biotechnol. 25:803-816(2007).
//
RX   PubMed=21295703; DOI=10.1016/j.cell.2010.12.032;
RA   Bock C., Kiskinis E., Verstappen G., Gu H.-C., Boulting G.L., Smith Z.D.,
RA   Ziller M.J., Croft G.F., Amoroso M.W., Oakley D.H., Gnirke A.,
RA   Eggan K.C., Meissner A.;
RT   "Reference maps of human ES and iPS cell variation enable
RT   high-throughput characterization of pluripotent cell lines.";
RL   Cell 144:439-452(2011).
//
RX   PubMed=21983960; DOI=10.1038/nmeth.1699;
RA   Phanstiel D.H., Brumbaugh J., Wenger C.D., Tian S.-L., Probasco M.D.,
RA   Bailey D.J., Swaney D.L., Tervo M.A., Bolin J.M., Ruotti V.,
RA   Stewart R., Thomson J.A., Coon J.J.;
RT   "Proteomic and phosphoproteomic comparison of human ES and iPS
RT   cells.";
RL   Nat. Methods 8:821-827(2011).
//
RX   PubMed=22315618; DOI=10.1155/2012/875059;
RA   Pekkanen-Mattila M., Ojala M., Kerkela E., Rajala K., Skottman H.,
RA   Aalto-Setala K.;
RT   "The effect of human and mouse fibroblast feeder cells on cardiac
RT   differentiation of human pluripotent stem cells.";
RL   Stem Cells Int. 2012:875059.1-875059.10(2012).
//
RX   PubMed=23117585; DOI=10.1016/j.scr.2012.09.002;
RA   Mallon B.S., Chenoweth J.G., Johnson K.R., Hamilton R.S., Tesar P.J.,
RA   Yavatkar A.S., Tyson L.J., Park K., Chen K.G., Fann Y.C., McKay R.D.G.;
RT   "StemCellDB: the human pluripotent stem cell database at the National
RT   Institutes of Health.";
RL   Stem Cell Res. 10:57-66(2013).
//
RX   PubMed=23341440; DOI=10.5966/sctm.2012-0047;
RA   Toivonen S., Ojala M., Hyysalo A., Ilmarinen T., Rajala K.,
RA   Pekkanen-Mattila M., Aanismaa R., Lundin K., Palgi J., Weltner J.,
RA   Trokovic R., Silvennoinen O., Skottman H., Narkilahti S.,
RA   Aalto-Setala K., Otonkoski T.;
RT   "Comparative analysis of targeted differentiation of human induced
RT   pluripotent stem cells (hiPSCs) and human embryonic stem cells reveals
RT   variability associated with incomplete transgene silencing in
RT   retrovirally derived hiPSC lines.";
RL   Stem Cells Transl. Med. 2:83-93(2013).
//
RX   PubMed=27293150; DOI=10.1016/j.stemcr.2016.05.006;
RA   Salomonis N., Dexheimer P.J., Omberg L., Schroll R., Bush S., Huo J.,
RA   Schriml L.M., Sui S.H., Keddache M., Mayhew C.N., Shanmukhappa S.K.,
RA   Wells J.M., Daily K., Hubler S., Wang Y.-L., Zambidis E.T., Margolin A.A.,
RA   Hide W.A., Hatzopoulos A.K., Malik P., Cancelas J.A., Aronow B.J.,
RA   Lutzko C.;
RT   "Integrated genomic analysis of diverse induced pluripotent stem cells
RT   from the Progenitor Cell Biology Consortium.";
RL   Stem Cell Reports 7:110-125(2016).
//
RX   PubMed=27688775; DOI=10.1155/2016/3826249;
RA   Nagaria P.K., Robert C., Park T.S., Huo J.S., Zambidis E.T.,
RA   Rassool F.V.;
RT   "High-fidelity reprogrammed human IPSCs have a high efficacy of DNA
RT   repair and resemble hESCs in their MYC transcriptional signature.";
RL   Stem Cells Int. 2016:3826249.1-3826249.14(2016).
//
RX   PubMed=28445466; DOI=10.1038/nature22312;
RA   Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C.,
RA   Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G.,
RA   Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A.,
RA   Eggan K.C.;
RT   "Human pluripotent stem cells recurrently acquire and expand dominant
RT   negative P53 mutations.";
RL   Nature 545:229-233(2017).
//
RX   PubMed=30388422; DOI=10.1016/j.stem.2018.10.009;
RA   Ludwig T.E., Kujak A., Rauti A., Andrzejewski S., Langbehn S.,
RA   Mayfield J., Fuller J., Yashiro Y., Hara Y., Bhattacharyya A.;
RT   "20 years of human pluripotent stem cell research: it all started with
RT   five lines.";
RL   Cell Stem Cell 23:644-648(2018).
//