ID   STA-ET-8.1
AC   CVCL_9695
SY   STA-ET-8; St. Anna Kinderspital-Ewing Tumor-8.1
DR   Cosmic; 2250478
DR   IARC_TP53; 23649
DR   Wikidata; Q54955781
RX   PubMed=8378080;
RX   PubMed=9393981;
RX   PubMed=25223734;
CC   From: Children's Cancer Research Institute; Vienna; Austria.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Thr (c.454C>A); Zygosity=Unspecified (PubMed=25223734).
DI   NCIt; C4817; Ewing sarcoma
DI   ORDO; Orphanet_319; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_9696 ! STA-ET-8.2
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 13
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RX   PubMed=8378080;
RA   Kovar H., Auinger A., Jug G., Aryee D.N.T., Zoubek A.,
RA   Salzer-Kuntschik M., Gadner H.;
RT   "Narrow spectrum of infrequent p53 mutations and absence of MDM2
RT   amplification in Ewing tumours.";
RL   Oncogene 8:2683-2690(1993).
//
RX   PubMed=9393981; DOI=10.1038/sj.onc.1201397;
RA   Kovar H., Jug G., Aryee D.N.T., Zoubek A., Ambros P.F., Gruber B.,
RA   Windhager R., Gadner H.;
RT   "Among genes involved in the RB dependent cell cycle regulatory
RT   cascade, the p16 tumor suppressor gene is frequently lost in the Ewing
RT   family of tumors.";
RL   Oncogene 15:2225-2232(1997).
//
RX   PubMed=25223734; DOI=10.1158/2159-8290.CD-14-0622; PMCID=PMC4264969;
RA   Tirode F., Surdez D., Ma X.-T., Parker M., Le Deley M.-C., Bahrami A.,
RA   Zhang Z.-J., Lapouble E., Grossetete-Lalami S., Rusch M., Reynaud S.,
RA   Rio-Frio T., Hedlund E., Wu G., Chen X., Pierron G., Oberlin O.,
RA   Zaidi S., Lemmon G., Gupta P., Vadodaria B., Easton J., Gut M.,
RA   Ding L., Mardis E.R., Wilson R.K., Shurtleff S., Laurence V.,
RA   Michon J., Marec-Berard P., Gut I.G., Downing J.R., Dyer M.A.,
RA   Zhang J.-H., Delattre O.;
RG   International Cancer Genome Consortium;
RG   St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project;
RT   "Genomic landscape of Ewing sarcoma defines an aggressive subtype with
RT   co-association of STAG2 and TP53 mutations.";
RL   Cancer Discov. 4:1342-1353(2014).
//