ID   FM81
AC   CVCL_9678
SY   FM-81
DR   cancercelllines; CVCL_9678
DR   Cosmic; 851415
DR   Cosmic; 2163777
DR   ECACC; 13012428
DR   ESTDAB; ESTDAB-026
DR   Wikidata; Q54835066
RX   PubMed=9288767;
RX   PubMed=9688544;
RX   PubMed=15592718;
RX   PubMed=23851445;
CC   HLA typing: A*02:01,68:01:02; B*15:01:01:01,44:02; C*03:03,07:04; DPB1*04:02; DQB1*05:01,03:01:01; DRB1*01:01,12:01 (PubMed=15592718).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799_1800delTGinsAA); ClinVar=VCV000376069; Zygosity=Unspecified (PubMed=23851445).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Pro38Ser (c.112C>T); ClinVar=VCV000127688; Zygosity=Unspecified (PubMed=9288767; PubMed=23851445).
CC   Derived from site: Metastatic; Not specified.
ST   Source(s): ECACC=13012428; ESTDAB=ESTDAB-026
ST   Amelogenin: X,Y
ST   CSF1PO: 13
ST   D13S317: 11
ST   D16S539: 11
ST   D3S1358: 14
ST   D5S818: 12,13
ST   D7S820: 9
ST   FGA: 20,26
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_9677 ! FM76
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 21
//
RX   PubMed=9288767;
RA   Guldberg P., thor Straten P., Birck A., Ahrenkiel V., Kirkin A.F.,
RA   Zeuthen J.;
RT   "Disruption of the MMAC1/PTEN gene by deletion or mutation is a
RT   frequent event in malignant melanoma.";
RL   Cancer Res. 57:3660-3663(1997).
//
RX   PubMed=9688544; DOI=10.1016/S0014-5793(98)00603-6;
RA   Dzhandzhugazyan K.N., Kirkin A.F., thor Straten P., Zeuthen J.;
RT   "Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated
RT   human melanomas.";
RL   FEBS Lett. 430:227-230(1998).
//
RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A.,
RA   Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G.,
RA   Garrido F.;
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
//
RX   PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006;
RA   Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L.,
RA   Borg A., Pawelec G., Guldberg P.;
RT   "Mutual exclusivity analysis of genetic and epigenetic drivers in
RT   melanoma identifies a link between p14 ARF and RARbeta signaling.";
RL   Mol. Cancer Res. 11:1166-1178(2013).
//