ID   CLB-Ge1
AC   CVCL_9530
SY   CLB-Ge
DR   ArrayExpress; E-MTAB-6654
DR   cancercelllines; CVCL_9530
DR   PRIDE; PXD011187
DR   Wikidata; Q54813560
RX   DOI=10.1007/0-306-46872-7_2;
RX   PubMed=7705946;
RX   PubMed=18923523;
RX   PubMed=20160348;
RX   PubMed=30459281;
CC   Sequence variation: Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Val (c.3520T>G); ClinVar=VCV000065670; Zygosity=Unspecified (PubMed=18923523; PubMed=30459281).
CC   Omics: Deep phosphoproteome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_9531 ! CLB-Ge2
SX   Male
AG   1Y6M
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 14
//
RX   DOI=10.1007/0-306-46872-7_2;
RA   Thiele C.J.;
RT   "Neuroblastoma.";
RL   (In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).
//
RX   PubMed=7705946; DOI=10.1002/ijc.2910610208;
RA   Combaret V., Turc-Carel C., Thiesse P., Rebillard A.-C., Frappaz D.,
RA   Haus O., Philip T., Favrot M.-C.;
RT   "Sensitive detection of numerical and structural aberrations of
RT   chromosome 1 in neuroblastoma by interphase fluorescence in situ
RT   hybridization. Comparison with restriction fragment length
RT   polymorphism and conventional cytogenetic analyses.";
RL   Int. J. Cancer 61:185-191(1995).
//
RX   PubMed=18923523; DOI=10.1038/nature07398;
RA   Janoueix-Lerosey I., Lequin D., Brugieres L., Ribeiro A.,
RA   de Pontual L., Combaret V., Raynal V., Puisieux A., Schleiermacher G.,
RA   Pierron G., Valteau-Couanet D., Frebourg T., Michon J., Lyonnet S.,
RA   Amiel J., Delattre O.;
RT   "Somatic and germline activating mutations of the ALK kinase receptor
RT   in neuroblastoma.";
RL   Nature 455:967-970(2008).
//
RX   PubMed=20160348; DOI=10.1172/JCI41013; PMCID=PMC2827960;
RA   Bouzas-Rodriguez J., Cabrera J.R., Delloye-Bourgeois C., Ichim G.,
RA   Delcros J.-G., Raquin M.-A., Rousseau R., Combaret V., Benard J.,
RA   Tauszig-Delamasure S., Mehlen P.;
RT   "Neurotrophin-3 production promotes human neuroblastoma cell survival
RT   by inhibiting TrkC-induced apoptosis.";
RL   J. Clin. Invest. 120:850-858(2010).
//
RX   PubMed=30459281; DOI=10.1126/scisignal.aar5680;
RA   Van den Eynden J., Umapathy G., Ashouri A., Cervantes-Madrid D.,
RA   Szydzik J., Ruuth K., Koster J., Larsson E., Guan J.-K., Palmer R.H.,
RA   Hallberg B.;
RT   "Phosphoproteome and gene expression profiling of ALK inhibition in
RT   neuroblastoma cell lines reveals conserved oncogenic pathways.";
RL   Sci. Signal. 11:eaar5680.1-eaar5680.16(2018).
//