ID   COST
AC   CVCL_9491
DR   Wikidata; Q54814334
RX   PubMed=15356658;
RX   PubMed=15356659;
RX   PubMed=16596703;
RX   PubMed=26657151;
CC   Sequence variation: Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:7910; NPM1; Name(s)=NPM1-ALK (PubMed=15356659; PubMed=26657151).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C37193; Anaplastic large cell lymphoma, ALK-positive
DI   ORDO; Orphanet_300895; ALK-positive anaplastic large cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   4Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 15
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RX   PubMed=15356658; DOI=10.1038/sj.leu.2403465;
RA   Drexler H.G., MacLeod R.A.F.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   anaplastic large-cell lymphoma.";
RL   Leukemia 18:1569-1571(2004).
//
RX   PubMed=15356659; DOI=10.1038/sj.leu.2403464;
RA   Lamant L., Espinos E., Duplantier M.-M., Dastugue N., Robert A.,
RA   Allouche M., Ragab-Thomas J.M.-F., Brousset P., Villalva C.,
RA   Gascoyne R.D., Al Saati T., Delsol G.;
RT   "Establishment of a novel anaplastic large-cell lymphoma-cell line
RT   (COST) from a 'small-cell variant' of ALCL.";
RL   Leukemia 18:1693-1698(2004).
//
RX   PubMed=16596703; DOI=10.1002/pmic.200500647;
RA   Cussac D., Pichereaux C., Colomba A., Capilla F., Pont F.,
RA   Gaits-Iacovoni F., Lamant L., Espinos E., Burlet-Schiltz O.,
RA   Monsarrat B., Delsol G., Payrastre B.;
RT   "Proteomic analysis of anaplastic lymphoma cell lines: identification
RT   of potential tumour markers.";
RL   Proteomics 6:3210-3222(2006).
//
RX   PubMed=26657151; DOI=10.1038/onc.2015.456; PMCID=PMC4907875;
RA   Ceccon M., Merlo M.E.B., Mologni L., Poggio T., Varesio L.M.,
RA   Menotti M., Bombelli S., Rigolio R., Manazza A.D., Di Giacomo F.,
RA   Ambrogio C., Giudici G., Casati C., Mastini C., Compagno M.,
RA   Turner S.D., Gambacorti-Passerini C., Chiarle R., Voena C.;
RT   "Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and
RT   drug dependency.";
RL   Oncogene 35:3854-3865(2016).
//