ID   BCLC-9
AC   CVCL_9483
SY   Barcelona Clinic Liver Cancer-9
DR   cancercelllines; CVCL_9483
DR   IARC_TP53; 20737
DR   Wikidata; Q54795691
RX   PubMed=15041736;
RX   PubMed=28751105;
CC   Characteristics: Established from a xenograft produced by implantation of tumor cells in the liver of a Swiss nude mice.
CC   Doubling time: 27.7 hours (Note=At 17th passage) (PubMed=15041736).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln192Arg (c.575A>G); ClinVar=VCV000182931; Zygosity=Unspecified (PubMed=15041736).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys242Tyr (c.725G>A); ClinVar=VCV000012354; Zygosity=Unspecified (PubMed=15041736).
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   70Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 19
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RX   PubMed=15041736; DOI=10.1158/1078-0432.CCR-03-1028;
RA   Armengol C., Tarafa G., Boix L., Sole M., Queralt R., Costa D.,
RA   Bachs O., Bruix J., Capella G.;
RT   "Orthotopic implantation of human hepatocellular carcinoma in mice:
RT   analysis of tumor progression and establishment of the BCLC-9 cell
RT   line.";
RL   Clin. Cancer Res. 10:2150-2157(2004).
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RX   PubMed=28751105; DOI=10.1016/j.virusres.2017.07.018;
RA   Coto-Llerena M., Koutsoudakis G., Boix L., Lopez-Oliva J.M.,
RA   Caro-Perez N., Fernandez-Carrillo C., Gonzalez P., Gastaminza P.,
RA   Bruix J., Forns X., Perez-del-Pulgar S.;
RT   "Permissiveness of human hepatocellular carcinoma cell lines for
RT   hepatitis C virus entry and replication.";
RL   Virus Res. 240:35-46(2017).
//