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Cellosaurus EML clone 1 (CVCL_9107)

[Text version]
Cell line name EML clone 1
Synonyms EML C1; EML Cell Line, Clone 1; EML
Accession CVCL_9107
Resource Identification Initiative To cite this cell line use: EML clone 1 (RRID:CVCL_9107)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11691.
Characteristics: KITLG dependent.
Doubling time: 18-20 hours (PubMed=7995521).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:9864; RARA (Note=With p.Gly404_Pro462del = RARalpha403).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Caution: ABM wrongly indicates that this cell line is immortalized using SV40 (ABM=T0679).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Basophil; CL=CL_0000767.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6 x DBA/2.
Hierarchy Children:
CVCL_D1L0 (EML clone 1.4)
Sex of cell Male
Category Factor-dependent cell line
Publications

PubMed=7995521; DOI=10.1101/gad.8.23.2831
Tsai S., Bartelmez S.H., Sitnicka E., Collins S.J.
Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development.
Genes Dev. 8:2831-2841(1994)

Patent=US5830760
Tsai S., Collins S.J.
Creating novel hematopoietic cell lines by expressing altered retinoic acid receptors.
Patent number US5830760, 03-Nov-1998

PubMed=9808058
Lawson N.D., Krause D.S., Berliner N.
Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines.
Exp. Hematol. 26:1178-1185(1998)

Cross-references
Cell line collections (Providers) ABM; T0679
ATCC; CRL-3610
ATCC; CRL-11691 - Discontinued
Cell line databases/resources CLO; CLO_0002925
Encyclopedic resources Wikidata; Q54832285
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number14