Cell line name |
MHH225 |
Synonyms |
MHH-225; MHH 225 |
Accession |
CVCL_8894 |
Resource Identification Initiative |
To cite this cell line use: MHH225 (RRID:CVCL_8894) |
Comments |
Problematic cell line: Contaminated. Shown to be a Jurkat derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from the bone marrow of a 60 year old male patient with acute myeloid leukemia. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00238. Population: Caucasian. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0065 (Jurkat) |
Sex of cell |
Male |
Age at sampling |
14Y |
Category |
Cancer cell line |
Web pages |
https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx |
Publications | PubMed=7548328; DOI=10.1007/BF01702645 Hassan H.T., Petershofen E.K., Lux E., Fonatsch C., Heil G., Freund M. Establishment and characterization of a novel CD34-positive human myeloid leukemia cell line: MHH225 growing in serum-free culture. Ann. Hematol. 71:111-117(1995) DOI=10.1016/B978-0-12-221970-2.50457-5 Drexler H.G. The leukemia-lymphoma cell line factsbook. (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001) PubMed=12592342; DOI=10.1038/sj.leu.2402799 Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F. False leukemia-lymphoma cell lines: an update on over 500 cell lines. Leukemia 17:416-426(2003) PubMed=20143388; DOI=10.1002/ijc.25242 Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I. Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_8894
|
Biological sample resources |
BioSample; SAMN03151807
|
Encyclopedic resources |
Wikidata; Q54905551
|
Entry history |
Entry creation | 06-Jun-2012 |
Last entry update | 02-May-2024 |
Version number | 26 |
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