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Cellosaurus KRJ-I (CVCL_8886)

[Text version]
Cell line name KRJ-I
Synonyms KRJ-1; KRJI; KRJ1
Accession CVCL_8886
Resource Identification Initiative To cite this cell line use: KRJ-I (RRID:CVCL_8886)
Comments Problematic cell line: Misclassified. Originally thought to arise from a multifocal carcinoid of the small intestine but shown to be an EBV-transformed lymphoblastoid cell line (PubMed=29444910; PubMed=31548718). Although misidentified, it has been argued that transcriptional regulation of the cells enough resemble gastroenteropancreatic neuroendocrine tumors to be used in studies (PubMed=31548719).
Population: Caucasian.
Doubling time: 1.8 days (PubMed=21544390).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Small intestine, ileum; UBERON=UBERON_0002116.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L295 ! KRJ-II
Sex of cell Male
Age at sampling 75Y
Category Transformed cell line
STR profile Source(s): PubMed=29444910


Run an STR similarity search on this cell line

PubMed=21544390; DOI=10.3892/ijo.8.3.513
Pfragner R., Wirnsberger G.H., Niederle B., Behmel A., Rinner I., Mandl A., Wawrina F., Luo J.-S., Adamiker D., Hoger H., Ingolic E., Schauenstein K.
Establishment of a continuous cell line from a human carcinoid of the small intestine (KRJ-I).
Int. J. Oncol. 8:513-520(1996)

PubMed=17242179; DOI=10.1677/jme.1.02037
Kidd M., Eick G.N., Modlin I.M., Pfragner R., Champaneria M.C., Murren J.R.
Further delineation of the continuous human neoplastic enterochromaffin cell line, KRJ-I, and the inhibitory effects of lanreotide and rapamycin.
J. Mol. Endocrinol. 38:181-192(2007)

PubMed=19295186; DOI=10.1159/000209330
Siddique Z.-L., Drozdov I., Floch J., Gustafsson B.I., Stunes K., Pfragner R., Kidd M., Modlin I.M.
KRJ-I and BON cell lines: defining an appropriate enterochromaffin cell neuroendocrine tumor model.
Neuroendocrinology 89:458-470(2009)

PubMed=22538498; DOI=10.1159/000338793
Grozinsky-Glasberg S., Shimon I., Rubinfeld H.
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=23119007; DOI=10.1371/journal.pone.0048411
Li S.-C., Martijn C., Cui T., Essaghir A., Luque R.M., Demoulin J.-B., Castano J.P., Oberg K., Giandomenico V.
The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells.
PLoS ONE 7:E48411-E48411(2012)

PubMed=29444910; DOI=10.1530/ERC-17-0445
Hofving T., Arvidsson Y., Almobarak B., Inge L., Pfragner R., Persson M., Stenman G., Kristiansson E., Johanson V., Nilsson O.
The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines.
Endocr. Relat. Cancer 25:367-380(2018)

PubMed=31548718; DOI=10.1038/s41588-019-0490-z
Hofving T., Karlsson J., Nilsson O., Nilsson J.A.
H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines.
Nat. Genet. 51:1426-1427(2019)

PubMed=31548719; DOI=10.1038/s41588-019-0509-5
Alvarez M.J., Yan P.-R., Alpaugh M.L., Bowden M., Sicinska E.T., Zhou C.-S.W., Karan C., Realubit R.B., Mundi P.S., Grunn A., Jager D., Chabot J.A., Fojo A.T., Oberstein P.E., Hibshoosh H., Milsom J.W., Kulke M.H., Loda M., Chiosis G., Reidy-Lagunes D.L., Califano A.
Reply to 'H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines'.
Nat. Genet. 51:1427-1428(2019)

Cell line collections (Providers) ECACC; 95041223 - Discontinued
Cell line databases/resources CLO; CLO_0007120
Encyclopedic resources Wikidata; Q54900482
Gene expression databases GEO; GSM600370
GEO; GSM830111
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number16