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Cellosaurus HeyA8-MDR (CVCL_8879)

[Text version]
Cell line name HeyA8-MDR
Synonyms HEYA8MDR
Accession CVCL_8879
Resource Identification Initiative To cite this cell line use: HeyA8-MDR (RRID:CVCL_8879)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Glu (c.1391G>A); ClinVar=VCV000013964; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8878 (HEY A8)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=16951177; DOI=10.1158/0008-5472.CAN-06-1410
Han L.Y., Landen C.N., Trevino J.G., Halder J., Lin Y.G., Kamat A.A., Kim T.-J., Merritt W.M., Coleman R.L., Gershenson D.M., Shakespeare W.C., Wang Y.-H., Sundaramoorth R., Metcalf C.A. III, Dalgarno D.C., Sawyer T.K., Gallick G.E., Sood A.K.
Antiangiogenic and antitumor effects of SRC inhibition in ovarian carcinoma.
Cancer Res. 66:8633-8639(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8879
Encyclopedic resources Wikidata; Q54883220
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number17