ID   EU-6
AC   CVCL_8864
SY   920; Line 920; Emory University-6
DR   cancercelllines; CVCL_8864
DR   IARC_TP53; 3826
DR   Wikidata; Q54832866
RX   PubMed=7630190;
RX   PubMed=7888679;
RX   PubMed=9108419;
RX   PubMed=9823951;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Leu (c.818G>T); ClinVar=VCV000376655; Zygosity=Unspecified (PubMed=7888679).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): COG
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 8,14
ST   D16S539: 9,12
ST   D18S51: 12,13,16
ST   D19S433: 12,14
ST   D21S11: 27,29
ST   D2S1338: 17,24,25
ST   D3S1358: 17
ST   D5S818: 11,12
ST   D7S820: 9
ST   D8S1179: 12,13
ST   FGA: 22,24
ST   TH01: 8,9.3
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   9Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 18
//
RX   PubMed=7630190;
RA   Zhou M.-X., Gu L.-B., James C.D., He J., Yeager A.M., Smith S.D.,
RA   Findley H.W. Jr.;
RT   "Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines
RT   established from children with acute lymphoblastic leukemia.";
RL   Leukemia 9:1159-1161(1995).
//
RX   PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608;
RA   Zhou M.-X., Yeager A.M., Smith S.D., Findley H.W. Jr.;
RT   "Overexpression of the MDM2 gene by childhood acute lymphoblastic
RT   leukemia cells expressing the wild-type p53 gene.";
RL   Blood 85:1608-1614(1995).
//
RX   PubMed=9108419; DOI=10.1182/blood.V89.8.2986;
RA   Findley H.W. Jr., Gu L.-B., Yeager A.M., Zhou M.-X.;
RT   "Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with
RT   p53 status and sensitivity to apoptosis in childhood acute
RT   lymphoblastic leukemia.";
RL   Blood 89:2986-2993(1997).
//
RX   PubMed=9823951; DOI=10.1038/sj.leu.2401198;
RA   Zhou M.-X., Gu L.-B., Yeager A.M., Findley H.W. Jr.;
RT   "Sensitivity to Fas-mediated apoptosis in pediatric acute
RT   lymphoblastic leukemia is associated with a mutant p53 phenotype and
RT   absence of Bcl-2 expression.";
RL   Leukemia 12:1756-1763(1998).
//