ID   A818-7
AC   CVCL_8777
AS   CVCL_8605
SY   A-818-7; A 818-7; 818-7
DR   cancercelllines; CVCL_8777
DR   Cosmic; 736268
DR   Cosmic; 933526
DR   Wikidata; Q54607229
RX   PubMed=1906154;
RX   PubMed=8105469;
RX   PubMed=8426738;
RX   PubMed=8430098;
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Unspecified (PubMed=8426738).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3890 ! A818
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 16
//
RX   PubMed=1906154;
RA   Kalthoff H., Roeder C., Humburg I., Thiele H.-G., Greten H.,
RA   Schmiegel W.H.;
RT   "Modulation of platelet-derived growth factor A- and B-chain/c-sis
RT   mRNA by tumor necrosis factor and other agents in adenocarcinoma
RT   cells.";
RL   Oncogene 6:1015-1021(1991).
//
RX   PubMed=8105469; DOI=10.1073/pnas.90.19.8972; PMCID=PMC47483;
RA   Kalthoff H., Roeder C., Gieseking J., Humburg I., Schmiegel W.H.;
RT   "Inverse regulation of human ERBB2 and epidermal growth factor
RT   receptors by tumor necrosis factor alpha.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:8972-8976(1993).
//
RX   PubMed=8426738;
RA   Kalthoff H., Schmiegel W.H., Roeder C., Kasche D., Schmidt A., Lauer G.,
RA   Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E.,
RA   Maurer J., Maacke H., Deppert W.;
RT   "p53 and K-RAS alterations in pancreatic epithelial cell lesions.";
RL   Oncogene 8:289-298(1993).
//
RX   PubMed=8430098; DOI=10.1073/pnas.90.3.863; PMCID=PMC45770;
RA   Schmiegel W.H., Roeder C., Schmielau J., Rodeck U., Kalthoff H.;
RT   "Tumor necrosis factor alpha induces the expression of transforming
RT   growth factor alpha and the epidermal growth factor receptor in human
RT   pancreatic cancer cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:863-867(1993).
//