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Cellosaurus OV1/VCR (CVCL_8746)

[Text version]
Cell line name OV1/VCR
Accession CVCL_8746
Resource Identification Initiative To cite this cell line use: OV1/VCR (RRID:CVCL_8746)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28445; Vincristine (VCR).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; 1100; BRCA1; Simple; p.Lys654Serfs*47 (c.1961delA); ClinVar=VCV000037438; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1101; BRCA2; Simple; p.Lys1108Argfs*11 (c.3323delA) (p.Gln1107fs) (c.3320delA); ClinVar=VCV000225716; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Arg38Cys (c.112C>T); ClinVar=VCV000376493; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Ter1069TrpinsLysAspAsn (c.3207A>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gly231Alafs*10 (c.692delG); ClinVar=VCV001756201; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Leu495Pro (c.1484T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser90Leufs*59 (c.267dupC) (c.267_268insC); ClinVar=VCV000634762; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Cys (c.377A>G); ClinVar=VCV000458541; Zygosity=Heterozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1304 (IGROV-1)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Publications

PubMed=2731146; DOI=10.1016/0165-4608(89)90227-6
Teyssier J.-R., Benard J., Ferre D., Da Silva J., Bettan-Renaud L.
Drug-related chromosomal changes in chemoresistant human ovarian carcinoma cells.
Cancer Genet. Cytogenet. 39:35-43(1989)

PubMed=2925277; DOI=10.1002/ijc.2910430322
Benard J., Da Silva J., Teyssier J.-R., Riou G.
Over-expression of MDR1 gene with no DNA amplification in a multiple-drug-resistant human ovarian carcinoma cell line.
Int. J. Cancer 43:471-477(1989)

PubMed=17934650; DOI=10.1590/S0100-879X2007001100014
Ait M'barek L., Ait Mouse H., Jaafari A., Aboufatima R., Benharref A., Kamal M., Benard J., El Abbadi N., Bensalah M., Gamouh A., Chait A., Dalal A., Zyad A.
Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy.
Braz. J. Med. Biol. Res. 40:1537-1544(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8746
Encyclopedic resources Wikidata; Q54936879
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22