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Cellosaurus OV1/CDDP (CVCL_8745)

[Text version]
Cell line name OV1/CDDP
Accession CVCL_8745
Resource Identification Initiative To cite this cell line use: OV1/CDDP (RRID:CVCL_8745)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; 1100; BRCA1; Simple; p.Lys654Serfs*47 (c.1961delA); ClinVar=VCV000037438; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1101; BRCA2; Simple; p.Lys1108Argfs*11 (c.3323delA) (p.Gln1107fs) (c.3320delA); ClinVar=VCV000225716; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Arg38Cys (c.112C>T); ClinVar=VCV000376493; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Ter1069TrpinsLysAspAsn (c.3207A>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gly231Alafs*10 (c.692delG); ClinVar=VCV001756201; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Leu495Pro (c.1484T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser90Leufs*59 (c.267dupC) (c.267_268insC); ClinVar=VCV000634762; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Cys (c.377A>G); ClinVar=VCV000458541; Zygosity=Heterozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1304 (IGROV-1)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Publications

PubMed=2731146; DOI=10.1016/0165-4608(89)90227-6
Teyssier J.-R., Benard J., Ferre D., Da Silva J., Bettan-Renaud L.
Drug-related chromosomal changes in chemoresistant human ovarian carcinoma cells.
Cancer Genet. Cytogenet. 39:35-43(1989)

PubMed=17934650; DOI=10.1590/S0100-879X2007001100014
Ait M'barek L., Ait Mouse H., Jaafari A., Aboufatima R., Benharref A., Kamal M., Benard J., El Abbadi N., Bensalah M., Gamouh A., Chait A., Dalal A., Zyad A.
Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy.
Braz. J. Med. Biol. Res. 40:1537-1544(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8745
Encyclopedic resources Wikidata; Q54936878
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22