| Cell line name |
OV1/ADR |
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| Synonyms |
OV1/DXR |
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| Accession |
CVCL_8744 |
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| Resource Identification Initiative |
To cite this cell line use: OV1/ADR (RRID:CVCL_8744) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
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| Sequence variations |
- Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Lys654Serfs*47 (c.1961delA); ClinVar=VCV000037438; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Lys1108Argfs*11 (c.3323delA) (p.Gln1107fs) (c.3320delA); ClinVar=VCV000225716; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Arg38Cys (c.112C>T); ClinVar=VCV000376493; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Ter1069TrpinsLysAspAsn (c.3207A>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); ClinVar=VCV002724056; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gly231Alafs*10 (c.692delG); ClinVar=VCV001756201; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Leu495Pro (c.1484T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Leufs*59 (c.267dupC) (c.267_268insC); ClinVar=VCV000634762; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Cys (c.377A>G); ClinVar=VCV000458541; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1304 (IGROV-1) |
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| Sex of cell |
Female |
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| Age at sampling |
47Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=2731146; DOI=10.1016/0165-4608(89)90227-6
Teyssier J.-R., Benard J., Ferre D., Da Silva J., Bettan-Renaud L.
Drug-related chromosomal changes in chemoresistant human ovarian carcinoma cells.
Cancer Genet. Cytogenet. 39:35-43(1989) PubMed=17934650; DOI=10.1590/S0100-879X2007001100014
Ait M'barek L., Ait Mouse H., Jaafari A., Aboufatima R., Benharref A., Kamal M., Benard J., El Abbadi N., Bensalah M., Gamouh A., Chait A., Dalal A., Zyad A.
Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy.
Braz. J. Med. Biol. Res. 40:1537-1544(2007) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_8744
|
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| Encyclopedic resources |
Wikidata; Q54936877
|
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 23 |
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