| Cell line name |
IGROV-1/25 ET |
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| Synonyms |
Igrov-1/25 ET |
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| Accession |
CVCL_8723 |
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| Resource Identification Initiative |
To cite this cell line use: IGROV-1/25 ET (RRID:CVCL_8723) |
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| Comments |
Population: Caucasian.
Doubling time: ~23 hours (PubMed=10817511).
Selected for resistance to: ChEBI; CHEBI:84050; Trabectedin (Ecteinascidin-743; ET-743).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
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| Sequence variations |
- Mutation; HGNC; 1100; BRCA1; Simple; p.Lys654Serfs*47 (c.1961delA); ClinVar=VCV000037438; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1101; BRCA2; Simple; p.Lys1108Argfs*11 (c.3323delA) (p.Gln1107fs) (c.3320delA); ClinVar=VCV000225716; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Arg38Cys (c.112C>T); ClinVar=VCV000376493; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Ter1069TrpinsLysAspAsn (c.3207A>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gly231Alafs*10 (c.692delG); ClinVar=VCV001756201; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Leu495Pro (c.1484T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Ser90Leufs*59 (c.267dupC) (c.267_268insC); ClinVar=VCV000634762; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Cys (c.377A>G); ClinVar=VCV000458541; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1304 (IGROV-1) |
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| Sex of cell |
Female |
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| Age at sampling |
47Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=10817511; DOI=10.1054/bjoc.2000.1224
Erba E., Bergamaschi D., Bassano L., Ronzoni S., Di Liberti G., Muradore I., Vignati S., Faircloth G.T., Jimeno J.M., D'Incalci M.
Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743).
Br. J. Cancer 82:1732-1739(2000) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_8723
|
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| Encyclopedic resources |
Wikidata; Q54897383
|
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 23 |
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