ID   HOC815
AC   CVCL_8703
SY   Hoc815; HOC-815
DR   CGH-DB; 357-2
DR   Cosmic; 930341
DR   Cosmic; 1046031
DR   Cosmic; 1123031
DR   IARC_TP53; 1099
DR   Wikidata; Q54890120
RX   PubMed=1570156;
RX   PubMed=1624295;
RX   PubMed=17052259;
RX   PubMed=17599052;
RX   PubMed=18097548;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr205Cys (c.614A>G); ClinVar=VCV000376681; Zygosity=Unspecified (PubMed=1570156).
CC   Derived from site: In situ; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 17
//
RX   PubMed=1570156;
RA   Sakai E., Tsuchida N.;
RT   "Most human squamous cell carcinomas in the oral cavity contain
RT   mutated p53 tumor-suppressor genes.";
RL   Oncogene 7:927-933(1992).
//
RX   PubMed=1624295; DOI=10.1002/hed.2880140103;
RA   Rikimaru K., Tadokoro K., Yamamoto T., Enomoto S., Tsuchida N.;
RT   "Gene amplification and overexpression of epidermal growth factor
RT   receptor in squamous cell carcinoma of the head and neck.";
RL   Head Neck 14:8-13(1992).
//
RX   PubMed=17052259; DOI=10.1111/j.1349-7006.2006.00343.x; PMCID=PMC11160012;
RA   Kozaki K.-i., Imoto I., Pimkhaokham A., Hasegawa S., Tsuda H.,
RA   Omura K., Inazawa J.;
RT   "PIK3CA mutation is an oncogenic aberration at advanced stages of oral
RT   squamous cell carcinoma.";
RL   Cancer Sci. 97:1351-1358(2006).
//
RX   PubMed=17599052; DOI=10.1038/sj.onc.1210589;
RA   Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N.,
RA   Kozaki K.-i., Amagasa T., Inazawa J.;
RT   "PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in
RT   oral squamous-cell carcinomas by aberrant promoter hypermethylation.";
RL   Oncogene 26:7921-7932(2007).
//
RX   PubMed=18097548; DOI=10.3892/ijo.32.1.101;
RA   Murugan A.K., Hong N.T., Fukui Y., Munirajan A.K., Tsuchida N.;
RT   "Oncogenic mutations of the PIK3CA gene in head and neck squamous cell
RT   carcinomas.";
RL   Int. J. Oncol. 32:101-111(2008).
//