ID   VACO 410
AC   CVCL_8632
SY   Vaco 410; VACO410; VaCo410; Vaco410; V410
DR   cancercelllines; CVCL_8632
DR   Cosmic; 2647364
DR   GEO; GSM784047
DR   Progenetix; CVCL_8632
DR   Wikidata; Q54992722
RX   PubMed=7824277;
RX   PubMed=8385345;
RX   PubMed=9927040;
RX   PubMed=11314036;
CC   Microsatellite instability: Stable (MSS) (PubMed=9927040).
CC   Sequence variation: Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Arg528His (c.1583G>A); ClinVar=VCV000012511; Zygosity=Homozygous (PubMed=9927040).
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   35Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 16
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RX   PubMed=7824277;
RA   Eshleman J.R., Lang E.Z., Bowerfind G.K., Parsons R., Vogelstein B.,
RA   Willson J.K.V., Veigl M.L., Sedwick W.D., Markowitz S.D.;
RT   "Increased mutation rate at the hprt locus accompanies microsatellite
RT   instability in colon cancer.";
RL   Oncogene 10:33-37(1995).
//
RX   PubMed=8385345; DOI=10.1073/pnas.90.7.2846; PMCID=PMC46193;
RA   Smith K.J., Johnson K.A., Bryan T.M., Hill D.E., Markowitz S.D.,
RA   Willson J.K.V., Paraskeva C., Petersen G.M., Hamilton S.R.,
RA   Vogelstein B., Kinzler K.W.;
RT   "The APC gene product in normal and tumor cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2846-2850(1993).
//
RX   PubMed=9927040;
RA   Grady W.M., Myeroff L.L., Swinler S.E., Rajput A., Thiagalingam S.,
RA   Lutterbaugh J.D., Neumann A., Brattain M.G., Chang J., Kim S.-J.,
RA   Kinzler K.W., Vogelstein B., Willson J.K.V., Markowitz S.D.;
RT   "Mutational inactivation of transforming growth factor beta receptor
RT   type II in microsatellite stable colon cancers.";
RL   Cancer Res. 59:320-324(1999).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L.,
RA   Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R.,
RA   Minna J.D.;
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//